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anti-ADRB2 antibody :: Rabbit anti-Human ADRB2 Polyclonal Antibody

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Catalog # MBS9414764
Unit / Price
  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $255 +1 FREE 8GB USB
Product Name

ADRB2, Polyclonal Antibody

Popular Item
Also Known As

ADRB2 Antibody

Product Synonym Names
Adrenoceptor beta 2, surface, BAR, B2AR, ADRBR, ADRB2R, BETA2AR
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
413
OMIM
109690
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody detects endogenous level of total ADRB2 protein.
Form/Format
Supplied at 0.7mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Immunogen Type
Peptide
Immunogen Description
Synthetic peptide corresponding to a region derived from 21-33 amino acids of Human adrenoceptor beta 2, surface
Predicted MW
46kd
Target Name
ADRB2
Preparation and Storage
Store at -20°C/1 year
Other Notes
Small volumes of anti-ADRB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADRB2 antibody
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Product Categories/Family for anti-ADRB2 antibody
Applications Tested/Suitable for anti-ADRB2 antibody
ELISA (EIA, Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ADRB2 antibody
ELISA: 1:1000-1:2000
Western blotting: 1:1000-1:2000
Immunohistochemistry: 1:15-1:50

Testing Data of anti-ADRB2 antibody
Gel: 10%SDS-PAGELane1: Hela cell lysateLane2: A549 cell lysateLysates: 30ug per lanePrimary antibody: 1/600 dilutionSecondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute
anti-ADRB2 antibody Testing Data image
Immunohistochemistry (IHC) of anti-ADRB2 antibody
The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using MBS9414764 (ADRB2 Antibody) at dilution 1/20, on the right is treated with the synthetic peptide.
anti-ADRB2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ADRB2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
beta-2 adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor beta 2, surface
NCBI Official Symbol
ADRB2  [Similar Products]
NCBI Official Synonym Symbols
BAR; B2AR; ADRBR; ADRB2R; BETA2AR
  [Similar Products]
NCBI Protein Information
beta-2 adrenergic receptor
UniProt Protein Name
Beta-2 adrenergic receptor
UniProt Synonym Protein Names
Beta-2 adrenoreceptor; Beta-2 adrenoceptor
UniProt Gene Name
ADRB2  [Similar Products]
UniProt Synonym Gene Names
ADRB2R; B2AR; Beta-2 adrenoceptor  [Similar Products]
UniProt Entry Name
ADRB2_HUMAN
NCBI Summary for ADRB2
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
UniProt Comments for ADRB2
ADRB2: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q31-q32

Cellular Component: lysosome; integral to plasma membrane; apical plasma membrane; plasma membrane; nucleus; receptor complex; endosome

Molecular Function: protein binding; potassium channel regulator activity; protein homodimerization activity; beta2-adrenergic receptor activity; norepinephrine binding; adenylate cyclase binding

Biological Process: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; diet induced thermogenesis; transmembrane receptor protein tyrosine kinase activation (dimerization); negative regulation of multicellular organism growth; regulation of vasodilation; adenylate cyclase activation; regulation of sodium ion transport; positive regulation of bone mineralization; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; positive regulation of protein ubiquitination; heat generation; negative regulation of smooth muscle contraction; brown fat cell differentiation; endosome to lysosome transport; positive regulation of transcription from RNA polymerase II promoter; response to cold; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; bone resorption

Disease: Obesity; Asthma, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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