• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-ADRBK1 antibody :: Rabbit anti-Human ADRBK1 Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS2526542
Unit / Price
  0.06 mL  /  $195 +1 FREE 8GB USB
  0.12 mL  /  $270 +1 FREE 8GB USB
  0.2 mL  /  $435 +1 FREE 8GB USB
Testing Data
Product Name

ADRBK1, Polyclonal Antibody

Full Product Name

ADRBK1 Antibody

Product Synonym Names
BARK1; BETA-ARK1; FLJ16718; GRK2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
109635
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of ADRBK1
Calculated Molecular Weight: 689aa; 80kd
Observed Molecular Weight: 80kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18409 / sc-562 / sc-8329
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ADRBK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ADRBK1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ADRBK1 antibody
WB: 1:500-1:5000
IHC: 1:50-1:200

Testing Data of anti-ADRBK1 antibody
anti-ADRBK1 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for ADRBK1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79,574 Da
NCBI Official Full Name
ADRBK1 protein
NCBI Official Synonym Full Names
adrenergic, beta, receptor kinase 1
NCBI Official Symbol
ADRBK1  [Similar Products]
NCBI Official Synonym Symbols
GRK2; BARK1; BETA-ARK1
  [Similar Products]
NCBI Protein Information
beta-adrenergic receptor kinase 1; G-protein coupled receptor kinase 2; beta-ARK-1
UniProt Protein Name
Beta-adrenergic receptor kinase 1
UniProt Synonym Protein Names
G-protein coupled receptor kinase 2
UniProt Gene Name
ADRBK1  [Similar Products]
UniProt Synonym Gene Names
BARK; BARK1; GRK2; Beta-ARK-1  [Similar Products]
UniProt Entry Name
ARBK1_HUMAN
NCBI Summary for ADRBK1
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]
UniProt Comments for ADRBK1
GRK2: a ubiquitous protein kinase of the GRK family. Phosphorylates the beta-2-adrenergic receptor and related G-protein-coupled receptors. Appears to mediate agonist-specific desensitization observed at high agonist concentrations. Expression level is consistently elevated in chronic human heart failure. Mouse models of severe heart failure have been used to demonstrate that inhibition of BARK1 with a peptide inhibitor is sufficient to increase mean survival, reduce dialation and improve cardiac function.

Protein type: EC 2.7.11.15; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; GRK family; BARK subfamily

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: G-protein coupled receptor kinase activity; protein binding; beta-adrenergic receptor kinase activity; Edg-2 lysophosphatidic acid receptor binding; alpha-2A adrenergic receptor binding; ATP binding; protein kinase activity

Biological Process: epidermal growth factor receptor signaling pathway; tachykinin signaling pathway; desensitization of G-protein coupled receptor protein signaling pathway; fibroblast growth factor receptor signaling pathway; acetylcholine receptor signaling, muscarinic pathway; nerve growth factor receptor signaling pathway; heart development; peptidyl-threonine phosphorylation; signal transduction; negative regulation of striated muscle contraction; peptidyl-serine phosphorylation; negative regulation of the force of heart contraction by chemical signal; phospholipase C activation; receptor internalization; innate immune response; positive regulation of catecholamine secretion; cardiac muscle contraction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000