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anti-ALDH7A1 antibody :: Rabbit anti-Human Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1) Polyclonal Antibody

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Catalog # MBS2075597 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
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  0.01 mg  /  $135 +1 FREE 8GB USB
  0.02 mg  /  $160 +1 FREE 8GB USB
  0.05 mg  /  $235 +1 FREE 8GB USB
  0.1 mg  /  $320 +1 FREE 8GB USB
  0.2 mg  /  $495 +1 FREE 8GB USB
  1 mg  /  $1,180 +1 FREE 8GB USB
anti-ALDH7A1 antibody
Product Name

Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1), Polyclonal Antibody

Full Product Name

APC-Linked Polyclonal Antibody to Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1)

Product Synonym Names
ATQ1; PDE; EPD; Antiquitin; Alpha-Aminoadipic Semialdehyde Dehydrogenase; Delta1-Piperideine-6-Carboxylate Dehydrogenease; P6c Dehydrogenase
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
S74728 mRNA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Concentration
200ug/ml (lot specific)
Immunogen
ALDH7A1 (Met1~Gln539)
Conjugation
APC
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2005697
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-ALDH7A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ALDH7A1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
NCBI/Uniprot data below describe general gene information for ALDH7A1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,411 Da
NCBI Official Full Name
aldehyde dehydrogenase 7 family, member A1, partial
NCBI Official Synonym Full Names
aldehyde dehydrogenase 7 family member A1
NCBI Official Symbol
ALDH7A1  [Similar Products]
NCBI Official Synonym Symbols
EPD; PDE; ATQ1
  [Similar Products]
NCBI Protein Information
alpha-aminoadipic semialdehyde dehydrogenase
UniProt Protein Name
Alpha-aminoadipic semialdehyde dehydrogenase
UniProt Synonym Protein Names
Aldehyde dehydrogenase family 7 member A1 (EC:1.2.1.3); Antiquitin-1; Betaine aldehyde dehydrogenase (EC:1.2.1.8); Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase
UniProt Gene Name
ALDH7A1  [Similar Products]
UniProt Synonym Gene Names
ATQ1; Alpha-AASA dehydrogenase; P6c dehydrogenase  [Similar Products]
NCBI Summary for ALDH7A1
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011]
UniProt Comments for ALDH7A1
ALDH7A1: Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. Defects in ALDH7A1 are the cause of pyridoxine-dependent epilepsy (PDE). PDE is characterized by a combination of various seizure types. It usually occurs in the first hours of life and is unresponsive to standard anticonvulsants, responding only to immediate administration of pyridoxine hydrochloride. Belongs to the aldehyde dehydrogenase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; EC 1.2.1.31; EC 1.2.1.8; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation

Chromosomal Location of Human Ortholog: 5q23.2

Cellular Component: cytoplasm; mitochondrial matrix; mitochondrion

Molecular Function: aldehyde dehydrogenase (NAD) activity; betaine-aldehyde dehydrogenase activity; L-aminoadipate-semialdehyde dehydrogenase activity; protein binding

Biological Process: aldehyde metabolic process; choline catabolic process; lysine catabolic process; sensory perception of sound

Disease: Epilepsy, Pyridoxine-dependent
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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