NP_001020527.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
anoctamin-6 isoform a
NCBI Official Synonym Full Names
anoctamin 6
NCBI Protein Information
anoctamin-6
UniProt Protein Name
Anoctamin-6
UniProt Synonym Protein Names
Small-conductance calcium-activated nonselective cation channel; SCAN channel; Transmembrane protein 16F
UniProt Synonym Gene Names
UniProt Entry Name
ANO6_HUMAN
NCBI Summary for ANO6
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
UniProt Comments for ANO6
ANO6: May act as a calcium-activated chloride channel. It is essential for calcium-dependent exposure of phosphatidylserine on the surface of activated platelets, a process necessary to trigger the clotting system. Defects in ANO6 are the cause of Scott syndrome (SCTS). A mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents. Belongs to the anoctamin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, ion channel; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: cell surface; membrane; plasma membrane; intracellular
Molecular Function: phospholipid scramblase activity; protein homodimerization activity; intracellular calcium activated chloride channel activity; voltage-gated ion channel activity; voltage-gated chloride channel activity; calcium activated cation channel activity
Biological Process: activation of blood coagulation via clotting cascade; dendritic cell chemotaxis; chloride transport; phospholipid scrambling; blood coagulation; lipid transport; transmembrane transport; cation transport
Disease: Scott Syndrome
Product References and Citations for anti-ANO6 antibody
Rose, J. Phd, et al. Mol. Med. (2010) In press : Hartzell, H.C., et al. J. Physiol. (Lond.) 587 (PT 10), 2127-2139 (2009) : Katoh, M., et al. Int. J. Oncol. 24(5):1345-1349(2004) Adams, M.D., et al. Nature 377 (6547 SUPPL), 3-174 (1995) :
Research Articles on ANO6
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Products associated with anti-ANO6 antibody
Pathways associated with anti-ANO6 antibody
Diseases associated with anti-ANO6 antibody
Organs/Tissues associated with anti-ANO6 antibody
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