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anti-SERPINF2 antibody :: Goat anti-Human Antiplasmin, alpha2 Polyclonal Antibody

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Catalog # MBS621539
Unit / Price
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  0.1 mg  /  $725 +1 FREE 8GB USB
anti-SERPINF2 antibody
Product Name

Antiplasmin, alpha2 (SERPINF2), Polyclonal Antibody

Full Product Name

Antiplasmin, alpha2 (Alpha2-antiplasmin, SERPINF2, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2, A2AP, AAP, ALPHA-2-PI, API, PLI, alpha-2-antiplasmin, alpha-2-plasmin inhibitor, serine (or cysteine

Product Synonym Names
Anti -Antiplasmin, alpha2 (Alpha2-antiplasmin, SERPINF2, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2, A2AP, AAP, ALPHA-2-PI, API, PLI, alpha-2-antiplasmin, alpha-2-plasmin inhibitor, serine (or cysteine
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (1646130..1658559). Location: 17p13
OMIM
262850
3D Structure
ModBase 3D Structure for P08697
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Specificity
Recognizes human Alpha2-antiplasmin at ~70kD in Human Duodenum and Ileum lysates (calculated MW of 54.6kD according to NP_000925.2). The observed MW corresponds to earlier findings in literature with different antibodies (Lee et al, Blood. 2004 May 15;103(10)
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Immunogen
Synthetic peptide corresponding to human Alpha2-antiplasmin.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-SERPINF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SERPINF2 antibody
alpha 2Antiplasmin (alpha,2AP), also known as alpha 2Plasmin Inhibitor (alpha 2PI), is a member of the SERPIN family of proteinase inhibitors and the primary inhibitor of the enzyme plasmin in blood. It is produced in the liver and circulates in plasma at ~70ug/ml (~1uM). alpha 2AP is a single chain molecule with a mass of 67kD as determined by SDS-PAGE. The primary target enzyme for alpha 2AP is plasmin, but alpha 2AP also acts as secondary or "backup" inhibitor of activated F.XI, activated Protein C and trypsin. Inhibition of these enzymes by alpha 2AP occurs by proteolytic cleavage after Arg364 with subsequent rapid formation of a stable, inactive 1:1 enzyme-alpha 2AP complex. alpha 2AP also acts to regulate fibrinolysis by binding to the lysine binding sites on plasminogen thus competitively inhibiting plasminogen binding to fibrin. About 30% of alpha 2AP present in plasma is partially degraded and lacks a peptide in the carboxyl region that contains the plasminogen-binding site. This form of alpha 2AP (~65kD) has a reduced rate of plasmin inhibition and has been referred to as the "slow form" of alpha 2AP. During fibrin formation, a portion of circulating alpha 2AP is cross-linked to the alpha -chain of fibrin by activated factor XIII, and this linking of plasmin inhibitor to the plasmin substrate provides an additional measure of protection to the fibrin clot from proteolysis by plasmin.
Applications Tested/Suitable for anti-SERPINF2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SERPINF2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:16000
Western Blot: 0.3-1ug/ml
NCBI/Uniprot data below describe general gene information for SERPINF2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,566 Da[Similar Products]
NCBI Official Full Name
alpha-2-antiplasmin isoform a
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
NCBI Official Symbol
SERPINF2  [Similar Products]
NCBI Official Synonym Symbols
AAP; API; PLI; A2AP; ALPHA-2-PI
  [Similar Products]
NCBI Protein Information
alpha-2-antiplasmin; serpin F2; alpha-2-AP; OTTHUMP00000115656; OTTHUMP00000197008; OTTHUMP00000197009; alpha-2-plasmin inhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
UniProt Protein Name
Alpha-2-antiplasmin
UniProt Synonym Protein Names
Alpha-2-plasmin inhibitor; Alpha-2-PI; Serpin F2
Protein Family
UniProt Gene Name
SERPINF2  [Similar Products]
UniProt Synonym Gene Names
AAP; PLI  [Similar Products]
UniProt Entry Name
A2AP_HUMAN
NCBI Summary for SERPINF2
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt Comments for SERPINF2
SERPINF2: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID). APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis. Belongs to the serpin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: extracellular space; cell surface; fibrinogen complex; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protein homodimerization activity; protease binding; endopeptidase inhibitor activity

Biological Process: response to organic substance; platelet activation; fibrinolysis; platelet degranulation; collagen fibril organization; negative regulation of fibrinolysis; renin-angiotensin regulation of blood vessel size; positive regulation of smooth muscle cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of stress fiber formation; acute-phase response; blood vessel morphogenesis; positive regulation of JNK cascade; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; blood coagulation

Disease: Alpha-2-plasmin Inhibitor Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-SERPINF2 antibody
 Reference Product  PubMed Publications
 F11 antibody  >1 publications with SERPINF2 and F11
Organs/Tissues associated with anti-SERPINF2 antibody
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