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anti-SERPINC1 antibody :: anti-Human antithrombin III antiserum Polyclonal Antibody

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Catalog # MBS135133
Unit / Price
  1 mL  /  $375 +1 FREE 8GB USB
  10 mL  /  $2,410 +3 FREE 8GB USB
anti-SERPINC1 antibody
Product Name

antithrombin III antiserum (SERPINC1), Polyclonal Antibody

Full Product Name

Rabbit anti human antithrombin III antiserum

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (173872942..173886516, complement). Location: 1q25.1
OMIM
107300
3D Structure
ModBase 3D Structure for P01008
Clonality
Polyclonal
Isotype
IgG
Host
Host: Rabbit; Source: Rabbit serum
Species Reactivity
Human
Purity/Purification
Serum
Form/Format
Frozen liquid
Concentration
Whole Antiserum (lot specific)
Immunogen
Full length native protein (purified) (Human).
Target Information
Recognises Antithrombin III
Target Molecular Weight
58200
Preparation and Storage
Store at -70 degree C. Shelf Life: 5 years from delivery
Other Notes
Small volumes of anti-SERPINC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SERPINC1 antibody
Polyclonal antiserum (host rabbit) to human antithrombin.
Applications Tested/Suitable for anti-SERPINC1 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for SERPINC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,602 Da
NCBI Official Full Name
antithrombin-III
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade C (antithrombin), member 1
NCBI Official Symbol
SERPINC1  [Similar Products]
NCBI Official Synonym Symbols
AT3; AT3D; ATIII; THPH7
  [Similar Products]
NCBI Protein Information
antithrombin-III; serpin C1; antithrombin III; serine-cysteine proteinase inhibitor clade C member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
UniProt Protein Name
Antithrombin-III
UniProt Synonym Protein Names
Serpin C1
Protein Family
UniProt Gene Name
SERPINC1  [Similar Products]
UniProt Synonym Gene Names
AT3; ATIII  [Similar Products]
UniProt Entry Name
ANT3_HUMAN
NCBI Summary for SERPINC1
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]
UniProt Comments for SERPINC1
SERPINC1: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D). AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin- binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 1q25.1

Cellular Component: extracellular space; extracellular region; plasma membrane

Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; protein binding; protease binding

Biological Process: negative regulation of inflammatory response; blood coagulation; response to nutrient

Disease: Antithrombin Iii Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-SERPINC1 antibody
 Reference Product  PubMed Publications
 PLG antibody  >2 publications with SERPINC1 and PLG
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