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anti-APLNR antibody :: Rabbit anti-Human APLNR Polyclonal Antibody

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Catalog # MBS7005599
Unit / Price
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  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

APLNR, Polyclonal Antibody

Popular Item
Full Product Name

APLNR Antibody

Product Synonym Names
Apelin receptor; APLNR; AGTRL1; APJ; Angiotensin receptor-like 1; G-protein coupled receptor APJ; G-protein coupled receptor HG11
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
600052
3D Structure
ModBase 3D Structure for P35414
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity Purified
Form/Format
Liquid
Immunogen
Recombinant human Apelin receptor protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-33838 / sc-33823
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-APLNR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-APLNR antibody
Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
Applications Tested/Suitable for anti-APLNR antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-APLNR antibody
Recommended dilution: IHC: 1:20-1:200

Immunohistochemistry (IHC) of anti-APLNR antibody
Immunohistochemistry of paraffin-embedded human colon cancer tissue using MBS7005599 at dilution 1:100
anti-APLNR antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-APLNR antibody
Immunofluorescent analysis of A431 cells using MBS7005599 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-APLNR antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for APLNR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
42,660 Da
NCBI Official Full Name
apelin receptor
NCBI Official Synonym Full Names
apelin receptor
NCBI Official Symbol
APLNR  [Similar Products]
NCBI Official Synonym Symbols
APJ; APJR; HG11; AGTRL1
  [Similar Products]
NCBI Protein Information
apelin receptor
UniProt Protein Name
Apelin receptor
UniProt Synonym Protein Names
Angiotensin receptor-like 1; G-protein coupled receptor APJ; G-protein coupled receptor HG11
Protein Family
UniProt Gene Name
APLNR  [Similar Products]
UniProt Synonym Gene Names
AGTRL1; APJ  [Similar Products]
UniProt Entry Name
APJ_HUMAN
NCBI Summary for APLNR
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]
UniProt Comments for APLNR
AGTRL1: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; gastrulation; heart development; regulation of body fluid levels
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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