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anti-ARHGDIB antibody :: Rabbit anti-Human ARHGDIB Polyclonal Antibody

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Catalog # MBS7047705
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

ARHGDIB, Polyclonal Antibody

Popular Item
Full Product Name

ARHGDIB Antibody

Product Synonym Names
Rho GDP-dissociation inhibitor 2Rho GDI 2; Ly-GDI1; ARHGDIB; GDIA2; GDID4; RAP1GN1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
L20688 mRNA
3D Structure
ModBase 3D Structure for P52566
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Rho GDP-dissociation inhibitor 2 protein (2-86AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-11359 / sc-32033 / sc-32034 / sc-32226 / sc-32227 / sc-6047
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ARHGDIB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARHGDIB antibody
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed: 8356058, PubMed: 7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed: 8262133).
Applications Tested/Suitable for anti-ARHGDIB antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-ARHGDIB antibody
WB: 1: 2000-1: 10000
IF: 1: 50-1: 200

Western Blot (WB) of anti-ARHGDIB antibody
Western Blot
Positive WB detected in:Jurkat whole cell lysate,Raji whole cell lysate,THP-1 whole cell lysate
All lanes: ARHGDIB antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 23 kDa
Observed band size: 23 kDa

anti-ARHGDIB antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-ARHGDIB antibody
Immunofluorescent analysis of HepG2 cells using MBS7047705 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-ARHGDIB antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for ARHGDIB. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,988 Da
NCBI Official Full Name
rho GDP-dissociation inhibitor 2
NCBI Official Synonym Full Names
Rho GDP dissociation inhibitor beta
NCBI Official Symbol
ARHGDIB  [Similar Products]
NCBI Official Synonym Symbols
D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2
  [Similar Products]
NCBI Protein Information
rho GDP-dissociation inhibitor 2
UniProt Protein Name
Rho GDP-dissociation inhibitor 2
UniProt Synonym Protein Names
Ly-GDI
UniProt Gene Name
ARHGDIB  [Similar Products]
UniProt Synonym Gene Names
GDIA2; GDID4; RAP1GN1; Rho GDI 2  [Similar Products]
UniProt Entry Name
GDIR2_HUMAN
NCBI Summary for ARHGDIB
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
UniProt Comments for ARHGDIB
RhoGDI beta: regulates the GDP/GTP exchange reaction of Rho proteins by inhibiting the dissociation of GDP from them, keeping these small GTPases in an inactive state. The GDIs are made up of two domains: a flexible N-terminal domain of about 70 amino acid residues and a folded 134-residue C-terminal domain. Regulates the GTP/GDP cycling of glucose-responsive small GTPases. Its phosphorylation on Y156, S101, and S174 mediates the cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion. Interacts with WNK1.

Protein type: Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol

Molecular Function: GTPase activity; protein binding; Rac GTPase binding; Rho GDP-dissociation inhibitor activity

Biological Process: cell motility; multicellular organismal development; negative regulation of cell adhesion; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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