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anti-ASCC1 antibody :: Rabbit anti-Human ASCC1 Polyclonal Antibody

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Catalog # MBS1493303
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

ASCC1, Polyclonal Antibody

Popular Item
Also Known As

ASCC1 Antibody

Product Synonym Names
Activating signal cointegrator 1 complex subunit 1; ASCC1; CGI-18; ASC-1 complex subunit p50; Trip4 complex subunit p50
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
357
OMIM
614215
3D Structure
ModBase 3D Structure for Q8N9N2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human Activating signal cointegrator 1 complex subunit 1 protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-160156
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ASCC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASCC1 antibody
Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin.
Applications Tested/Suitable for anti-ASCC1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ASCC1 antibody
Recommended dilution: IHC:1:20-1:200

Western Blot (WB) of anti-ASCC1 antibody
Western Blot
Positive WB detected in:Hela whole cell lysate,HEK293 whole cell lysate,Jurkat whole cell lysate,Mouse heart tissue,Mouse liver tissue,Mouse lung tissue,Mouse kidney tissue,Mouse brain tissue,Mouse stomach tissue
All lanes: ASCC1 antibody at 2.7ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46,42 kDa
Observed band size: 46 kDa

anti-ASCC1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ASCC1 antibody
Immunohistochemistry of paraffin-embedded human tonsil using MBS1493303 at dilution of 1:100
anti-ASCC1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ASCC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,228 Da
NCBI Official Full Name
activating signal cointegrator 1 complex subunit 1 isoform b
NCBI Official Synonym Full Names
activating signal cointegrator 1 complex subunit 1
NCBI Official Symbol
ASCC1  [Similar Products]
NCBI Official Synonym Symbols
p50; CGI-18; ASC1p50
  [Similar Products]
NCBI Protein Information
activating signal cointegrator 1 complex subunit 1
UniProt Protein Name
Activating signal cointegrator 1 complex subunit 1
UniProt Synonym Protein Names
ASC-1 complex subunit p50; Trip4 complex subunit p50
UniProt Gene Name
ASCC1  [Similar Products]
UniProt Entry Name
ASCC1_HUMAN
NCBI Summary for ASCC1
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for ASCC1
ASCC1: Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. Defects in ASCC1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in ASCC1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 10pter-q25.3

Cellular Component: cytoplasm; nucleoplasm; transcription factor complex

Molecular Function: protein binding; RNA binding

Biological Process: DNA dealkylation; DNA repair; regulation of transcription, DNA-dependent; transcription, DNA-dependent

Disease: Barrett Esophagus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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