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anti-GOT2 antibody :: Rabbit anti-Human Aspartate aminotransferase, mitochondrial Polyclonal Antibody

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Catalog # MBS7006066
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

Aspartate aminotransferase, mitochondrial (GOT2), Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human Aspartate aminotransferase, mitochondrial polyclonal Antibody

Product Synonym Names
GOT2; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
387
OMIM
138150
3D Structure
ModBase 3D Structure for P00505
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Form/Format
Liquid
Immunogen
Recombinant human Aspartate aminotransferase, mitochondrial protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46707 / sc-46704
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-GOT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GOT2 antibody
Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.
Product Categories/Family for anti-GOT2 antibody
Applications Tested/Suitable for anti-GOT2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-GOT2 antibody
Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

Western Blot (WB) of anti-GOT2 antibody
Western blot
All lanes: Aspartate aminotransferase, mitochondrial antibody at 2ug/ml
lane 1:EC109 whole cell lysate
lane 2:293T whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 48,44 kDa
Observed band size: 47 kDa

anti-GOT2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-GOT2 antibody
Immunohistochemistry of paraffin-embedded human liver tissue using MBS7006066 at dilution 1:100
anti-GOT2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-GOT2 antibody
Immunofluorescent analysis of MCF-7 cells using MBS7006066 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-GOT2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for GOT2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,030 Da[Similar Products]
NCBI Official Full Name
aspartate aminotransferase, mitochondrial isoform 2
NCBI Official Synonym Full Names
glutamic-oxaloacetic transaminase 2
NCBI Official Symbol
NCBI Official Synonym Symbols
KAT4; KATIV; mitAAT
  [Similar Products]
NCBI Protein Information
aspartate aminotransferase, mitochondrial
UniProt Protein Name
Aspartate aminotransferase, mitochondrial
UniProt Synonym Protein Names
Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A
UniProt Gene Name
UniProt Synonym Gene Names
mAspAT; FABP-1; FABPpm  [Similar Products]
UniProt Entry Name
AATM_HUMAN
NCBI Summary for GOT2
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
UniProt Comments for GOT2
GOT2: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Amino Acid Metabolism - tyrosine; EC 2.6.1.7; Mitochondrial; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 2.6.1.1; Transferase

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: cell surface; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; myelin sheath; perikaryon; plasma membrane; protein complex

Molecular Function: amino acid binding; aspartate transaminase activity; enzyme binding; identical protein binding; kynurenine-oxoglutarate transaminase activity; phospholipid binding; protein homodimerization activity; pyridoxal phosphate binding

Biological Process: 2-oxoglutarate metabolic process; 4-hydroxyproline catabolic process; amino acid biosynthetic process; aspartate biosynthetic process; aspartate catabolic process; aspartate metabolic process; carbohydrate metabolic process; fatty acid transport; gluconeogenesis; glucose metabolic process; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; glutamate metabolic process; oxaloacetate metabolic process; response to ethanol
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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