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anti-ASPM antibody :: Rabbit anti-Human ASPM Polyclonal Antibody

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Catalog # MBS9602923
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Product Name

ASPM, Polyclonal Antibody

Popular Item
Also Known As

ASPM Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1892
3D Structure
ModBase 3D Structure for Q8IZT6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
ASPM antibody detects endogenous levels of total ASPM
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human ASPM
Subcellular Location
Cytoskeleton; Nucleus
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-ASPM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASPM antibody
Function: Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.
Subunit Structure: Interacts with KATNA1 and KATNB1; katanin complex formation KATNA1:KATNB1 is required for the association.
Applications Tested/Suitable for anti-ASPM antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ASPM antibody
WB: 1:1000-3000

Western Blot (WB) of anti-ASPM antibody
Western blot analysis of extracts from various samples, using ASPM Antibody. Lane 1: 293 treated with blocking peptide. Lane 2: 293; Lane 3: Hela;
anti-ASPM antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-ASPM antibody
Western blot analysis of ASPM using HeLa whole cell lysates
anti-ASPM antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ASPM. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 410 kDa
Predicted: 410 kDa
NCBI Official Full Name
abnormal spindle-like microcephaly-associated protein isoform 2
NCBI Official Synonym Full Names
abnormal spindle microtubule assembly
NCBI Official Symbol
NCBI Official Synonym Symbols
ASP; MCPH5; Calmbp1
  [Similar Products]
NCBI Protein Information
abnormal spindle-like microcephaly-associated protein
UniProt Protein Name
Abnormal spindle-like microcephaly-associated protein
UniProt Synonym Protein Names
Abnormal spindle protein homolog; Asp homolog
UniProt Gene Name
UniProt Synonym Gene Names
MCPH5; Asp homolog  [Similar Products]
NCBI Summary for ASPM
This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
UniProt Comments for ASPM
Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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