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anti-ATM antibody :: Rabbit anti-Human Ataxia Telangiectasia Mutated (ATM) Polyclonal Antibody

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Catalog # MBS2093193
Unit / Price
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  0.1 mg  /  $235 +1 FREE 8GB USB
  0.2 mg  /  $350 +1 FREE 8GB USB
  1 mg  /  $835 +1 FREE 8GB USB
anti-ATM antibody
Product Name

Ataxia Telangiectasia Mutated (ATM), Polyclonal Antibody

Full Product Name

Biotin-Linked Polyclonal Antibody to Ataxia Telangiectasia Mutated (ATM)

Product Synonym Names
AT1; ATD; ATA; ATC; ATDC; ATE; TEL1; TELO1; Serine-protein kinase ATM
Product Gene Name
Matching Pairs
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
U33841 mRNA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Concentration
200ug/ml (lot specific)
Conjugation
Biotin
Immunogen
ATM (Val2484~Arg2748)
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-ATM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ATM antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for ATM. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
350,687 Da
NCBI Official Full Name
Ataxia telangiectasia mutated
NCBI Official Synonym Full Names
ATM serine/threonine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
  [Similar Products]
NCBI Protein Information
serine-protein kinase ATM
UniProt Protein Name
Serine-protein kinase ATM
UniProt Synonym Protein Names
Ataxia telangiectasia mutated; A-T mutated
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
A-T mutated  [Similar Products]
NCBI Summary for ATM
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
UniProt Comments for ATM
ATM: an atypical kinase of the PIKK family. Regulates cell cycle checkpoints and DNA repair . May function as a tumor suppressor. Activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Involved in the activation of ABL1 and SAPK. Binds DNA ends and is part of the BRCA1- associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. LOF mutations associated with ataxia telangiectasia, causing progressive loss of motor control (ataxia), dilation of superficial blood vessels (telangiectasia), cancer and immune deficiency. Approximately 30% of cases develop tumors, mostly lymphomas and leukemias, due to defects in DNA damage repair. Somatic mutations seen in leukemias and lymphomas.

Protein type: ATYPICAL group; DNA repair, damage; EC 2.7.11.1; Kinase, protein; PIKK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: chromosome, telomeric region; cytoplasmic vesicle; DNA repair complex; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus; spindle

Molecular Function: 1-phosphatidylinositol-3-kinase activity; ATP binding; DNA binding; DNA-dependent protein kinase activity; lipid transporter activity; protein binding; protein complex binding; protein dimerization activity; protein N-terminus binding; protein serine/threonine kinase activity

Biological Process: brain development; cell cycle arrest; cellular response to DNA damage stimulus; cellular response to gamma radiation; cellular response to nitrosative stress; cellular response to X-ray; determination of adult lifespan; DNA damage induced protein phosphorylation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction resulting in induction of apoptosis; DNA double-strand break processing; DNA repair; DNA replication; DNA synthesis involved in DNA repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; female meiotic nuclear division; heart development; histone phosphorylation; immunoglobulin production; lipid transport; lipoprotein catabolic process; male meiotic nuclear division; meiotic telomere clustering; mitotic cell cycle spindle assembly checkpoint; multicellular organism growth; negative regulation of B cell proliferation; negative regulation of telomere capping; negative regulation of TORC1 signaling; neuron apoptosis; oocyte development; ovarian follicle development; peptidyl-serine phosphorylation; positive regulation of apoptosis; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of histone phosphorylation; positive regulation of neuron apoptotic process; positive regulation of telomerase catalytic core complex assembly; positive regulation of telomere maintenance via telomerase; positive regulation of telomere maintenance via telomere lengthening; post-embryonic development; pre-B cell allelic exclusion; protein amino acid phosphorylation; protein autophosphorylation; reciprocal meiotic recombination; regulation of apoptosis; regulation of autophagy; regulation of cellular response to heat; regulation of microglial cell activation; regulation of telomerase activity; regulation of telomere maintenance via telomerase; replicative senescence; response to hypoxia; response to ionizing radiation; signal transduction; signal transduction involved in mitotic G2 DNA damage checkpoint; somitogenesis; strand displacement; telomere maintenance; thymus development; V(D)J recombination

Disease: Ataxia-telangiectasia; Breast Cancer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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