NP_116241.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,497 Da
NCBI Official Full Name
cysteine protease ATG4C
NCBI Official Synonym Full Names
autophagy related 4C cysteine peptidase
NCBI Protein Information
cysteine protease ATG4C
UniProt Protein Name
Cysteine protease ATG4C
UniProt Synonym Protein Names
AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C
UniProt Synonym Gene Names
NCBI Summary for ATG4C
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for ATG4C
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Research Articles on ATG4C
Precautions
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Products associated with anti-ATG4C antibody
Pathways associated with anti-ATG4C antibody
Diseases associated with anti-ATG4C antibody
Organs/Tissues associated with anti-ATG4C antibody
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