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anti-ATM antibody :: Rabbit anti-Human ATM Polyclonal Antibody

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Catalog # MBS241245
Unit / Price
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  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

ATM, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human ATM

Product Synonym Names
Anti-ATM Antibody (C-Terminus) IHC-plus; ATM; A-T mutated; ATA; ATC; ATD; ATE; AT mutated; Ataxia telangiectasia; ATDC; Serine-protein kinase ATM; AT1; Ataxia telangiectasia mutated; TEL1; TELO1; Human ATM
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
phenotype 607585
3D Structure
ModBase 3D Structure for Q13315
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
peptide corresponding to 14 amino acids near the carboxy terminus of human ATM
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
A peptide corresponding to 14 amino acids near the carboxy terminus of human ATM.
Immunogen Type
Synthetic peptide
Immunogen
ATM antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human ATM.
Antigen Modification
C-Terminus
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Other Notes
Small volumes of anti-ATM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ATM antibody
The ATM gene product is a 370 kD nuclear phosphoprotein with C-terminal homology to phosphatidylinositol 3-kinase. ATM is involved in the induction of a DNA damage control pathway. Mutations in the ATM gene cause neuronal degeneration, gonadal abnormalities, and immune deficiencies as part of the hereditary disease ataxia telangiectasia.
Applications Tested/Suitable for anti-ATM antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-ATM antibody
IHC-P (1 - 2 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-ATM antibody
Anti-ATM antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
anti-ATM antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ATM antibody
Anti-ATM antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
anti-ATM antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-ATM antibody
Immunofluorescence of ATM in Human Lymph Node cells with ATM antibody at 10 ug/ml.
anti-ATM antibody Immunofluorescence (IF) image
Western Blot (WB) of anti-ATM antibody
Western blot of ATM in Daudi whole cell lysate with ATM antibody at (A) 1 and (B) 2 ug/ml.
anti-ATM antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ATM. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
350,687 Da
NCBI Official Full Name
serine-protein kinase ATM
NCBI Official Synonym Full Names
ATM serine/threonine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
  [Similar Products]
NCBI Protein Information
serine-protein kinase ATM; AT mutated; A-T mutated; ataxia telangiectasia mutated; TEL1, telomere maintenance 1, homolog
UniProt Protein Name
Serine-protein kinase ATM
UniProt Synonym Protein Names
Ataxia telangiectasia mutated; A-T mutated
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
A-T mutated  [Similar Products]
UniProt Entry Name
ATM_HUMAN
NCBI Summary for ATM
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
UniProt Comments for ATM
ATM: an atypical kinase of the PIKK family. Regulates cell cycle checkpoints and DNA repair . May function as a tumor suppressor. Activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Involved in the activation of ABL1 and SAPK. Binds DNA ends and is part of the BRCA1- associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. LOF mutations associated with ataxia telangiectasia, causing progressive loss of motor control (ataxia), dilation of superficial blood vessels (telangiectasia), cancer and immune deficiency. Approximately 30% of cases develop tumors, mostly lymphomas and leukemias, due to defects in DNA damage repair. Somatic mutations seen in leukemias and lymphomas.

Protein type: Kinase, protein; Protein kinase, atypical; Tumor suppressor; DNA repair, damage; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; PIKK family

Chromosomal Location of Human Ortholog: 11q22-q23

Cellular Component: nucleoplasm; chromosome, telomeric region; cytoplasmic membrane-bound vesicle; spindle

Molecular Function: protein dimerization activity; protein serine/threonine kinase activity; protein binding; DNA binding; 1-phosphatidylinositol-3-kinase activity; protein complex binding; protein N-terminus binding; DNA-dependent protein kinase activity; histone serine kinase activity; ATP binding

Biological Process: lipoprotein catabolic process; DNA damage induced protein phosphorylation; positive regulation of apoptosis; protein amino acid autophosphorylation; heart development; pre-B cell allelic exclusion; negative regulation of B cell proliferation; signal transduction; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; protein amino acid phosphorylation; positive regulation of neuron apoptosis; double-strand break repair; mitotic cell cycle spindle assembly checkpoint; cell cycle arrest; telomere maintenance; somitogenesis; V(D)J recombination; DNA repair; double-strand break repair via homologous recombination; peptidyl-serine phosphorylation; neuron apoptosis; DNA damage response, signal transduction resulting in induction of apoptosis; meiotic recombination; response to hypoxia; brain development; response to ionizing radiation; positive regulation of DNA damage response, signal transduction by p53 class mediator; response to DNA damage stimulus; oocyte development

Disease: Breast Cancer; Ataxia-telangiectasia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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