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anti-KCNJ1 antibody :: Rabbit anti-Human ATP-sensitive inward rectifier potassium channel 1 Polyclonal Antibody

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Catalog # MBS7006796
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

ATP-sensitive inward rectifier potassium channel 1 (KCNJ1), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human ATP-sensitive inward rectifier potassium channel 1 polyclonal Antibody

Product Synonym Names
ATP-regulated potassium channel ROM-K Inward rectifier K(+) channel Kir1.1 Potassium channel; inwardly rectifying subfamily J member 1 KCNJ1 ROMK1
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
241200
3D Structure
ModBase 3D Structure for P48048
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Form/Format
Liquid
Immunogen
Recombinant human ATP-sensitive inward rectifier potassium channel 1 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-10692 / sc-10694
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-KCNJ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KCNJ1 antibody
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. This protein is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-KCNJ1 antibody
Applications Tested/Suitable for anti-KCNJ1 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-KCNJ1 antibody
Recommended dilution: WB:1:500-2000

Western Blot (WB) of anti-KCNJ1 antibody
Western blot
All lanes: ATP-sensitive inward rectifier potassium channel 1 antibody at 2ug/ml
Lane 1:HepG2 whole cell lysate
Lane 2:Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 45,43 kDa
Observed band size: 45 kDa

anti-KCNJ1 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-KCNJ1 antibody
Immunofluorescent analysis of Hela cells using MBS7006796 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-KCNJ1 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for KCNJ1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,611 Da[Similar Products]
NCBI Official Full Name
ATP-sensitive inward rectifier potassium channel 1 isoform a
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily J member 1
NCBI Official Symbol
KCNJ1  [Similar Products]
NCBI Official Synonym Symbols
ROMK; ROMK1; KIR1.1
  [Similar Products]
NCBI Protein Information
ATP-sensitive inward rectifier potassium channel 1
UniProt Protein Name
ATP-sensitive inward rectifier potassium channel 1
UniProt Synonym Protein Names
ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; Potassium channel, inwardly rectifying subfamily J member 1
UniProt Gene Name
KCNJ1  [Similar Products]
UniProt Synonym Gene Names
ROMK1  [Similar Products]
UniProt Entry Name
KCNJ1_HUMAN
NCBI Summary for KCNJ1
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNJ1
In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Organs/Tissues associated with anti-KCNJ1 antibody
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