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anti-KCNJ10 antibody :: Rabbit anti-Human ATP-sensitive inward rectifier potassium channel 10 Polyclonal Antibody

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Catalog # MBS1496426
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

ATP-sensitive inward rectifier potassium channel 10 (KCNJ10), Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human ATP-sensitive inward rectifier potassium channel 10 polyclonal Antibody

Product Synonym Names
ATP-dependent inwardly rectifying potassium channel Kir4.1; Inward rectifier K(+) channel Kir1.2; Potassium channel; inwardly rectifying subfamily J member 10; KCNJ10
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
379
OMIM
602208
3D Structure
ModBase 3D Structure for P78508
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human ATP-sensitive inward rectifier potassium channel 10 protein(165-379aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23637
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-KCNJ10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KCNJ10 antibody
May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
Applications Tested/Suitable for anti-KCNJ10 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunohistochemistry (IHC) of anti-KCNJ10 antibody
Immunohistochemistry of paraffin-embedded human epityphlon tissue using MBS1496426 at dilution 1:100
anti-KCNJ10 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-KCNJ10 antibody
Immunohistochemistry of paraffin-embedded human placenta tissue using MBS1496426 at dilution 1:100
anti-KCNJ10 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-KCNJ10 antibody
Immunofluorescent analysis of Hela cells using MBS1496426 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-KCNJ10 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for KCNJ10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,508 Da[Similar Products]
NCBI Official Full Name
ATP-sensitive inward rectifier potassium channel 10
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily J member 10
NCBI Official Symbol
KCNJ10  [Similar Products]
NCBI Official Synonym Symbols
KIR1.2; KIR4.1; SESAME; BIRK-10; KCNJ13-PEN
  [Similar Products]
NCBI Protein Information
ATP-sensitive inward rectifier potassium channel 10
UniProt Protein Name
ATP-sensitive inward rectifier potassium channel 10
UniProt Synonym Protein Names
ATP-dependent inwardly rectifying potassium channel Kir4.1; Inward rectifier K(+) channel Kir1.2; Potassium channel, inwardly rectifying subfamily J member 10
UniProt Gene Name
KCNJ10  [Similar Products]
UniProt Entry Name
KCJ10_HUMAN
NCBI Summary for KCNJ10
This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNJ10
Kir4.1: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Defects in KCNJ10 are the cause of seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES). A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Channel, potassium

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: ATP binding; ATP-activated inward rectifier potassium channel activity; protein binding

Biological Process: adult walking behavior; glutamate uptake during transmission of nerve impulse; myelination in the central nervous system; potassium ion homeostasis; potassium ion import; potassium ion transport; regulation of long-term neuronal synaptic plasticity; regulation of resting membrane potential; synaptic transmission; visual perception

Disease: Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct; Pendred Syndrome; Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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