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anti-ATG16L1 antibody :: Rabbit anti-Human Autophagy-related protein 16-1 Polyclonal Antibody

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Catalog # MBS1497386
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

Autophagy-related protein 16-1 (ATG16L1), Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human Autophagy-related protein 16-1 polyclonal Antibody(ATG16L1)

Product Synonym Names
APG16-like 1; ATG16L1; APG16L; UNQ9393/PRO34307
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
523
OMIM
610767
3D Structure
ModBase 3D Structure for Q676U5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Autophagy-related protein 16-1 protein(90-300aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-70133 / sc-70134
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ATG16L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ATG16L1 antibody
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.
Applications Tested/Suitable for anti-ATG16L1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ATG16L1 antibody
Recommended dilution: WB:1:200-2000
IHC:1:20-1:200

Western Blot (WB) of anti-ATG16L1 antibody
All lanes: Autophagy-related protein 16-1 antibody at 2ug/ml+MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 69,67,54,48,50 kDa
Observed band size: 68 kDa

anti-ATG16L1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ATG16L1 antibody
Immunohistochemistry of paraffin-embedded human placenta using MBS1497386 at dilution 1:100
anti-ATG16L1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ATG16L1 antibody
Immunohistochemistry of paraffin-embedded human spleen using MBS1497386 at dilution 1:100
anti-ATG16L1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ATG16L1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,486 Da
NCBI Official Full Name
autophagy-related protein 16-1 isoform 4
NCBI Official Synonym Full Names
autophagy related 16 like 1
NCBI Official Symbol
ATG16L1  [Similar Products]
NCBI Official Synonym Symbols
IBD10; WDR30; APG16L; ATG16A; ATG16L
  [Similar Products]
NCBI Protein Information
autophagy-related protein 16-1
UniProt Protein Name
Autophagy-related protein 16-1
UniProt Synonym Protein Names
APG16-like 1
Protein Family
UniProt Gene Name
ATG16L1  [Similar Products]
UniProt Synonym Gene Names
APG16L  [Similar Products]
UniProt Entry Name
A16L1_HUMAN
NCBI Summary for ATG16L1
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
UniProt Comments for ATG16L1
ATG16L1: Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral; Adaptor/scaffold; Autophagy

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: autophagic vacuole; axoneme; cytosol; pre-autophagosomal structure membrane

Molecular Function: identical protein binding; protein binding; small conjugating protein ligase activity

Biological Process: autophagic vacuole formation; macroautophagy; protein homooligomerization; protein transport

Disease: Inflammatory Bowel Disease 10
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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