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anti-BCL10 antibody :: Rabbit anti-Human B-cell lymphoma/leukemia 10 Polyclonal Antibody

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Catalog # MBS7005827
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

B-cell lymphoma/leukemia 10 (BCL10), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human B-cell lymphoma/leukemia 10 polyclonal Antibody

Product Synonym Names
Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; cCARMEN; Cellular-E10; c-E10; mE10; BCL10; CIPER; CLAP
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
603517
3D Structure
ModBase 3D Structure for O95999
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Form/Format
Liquid
Immunogen
Recombinant human B-cell lymphoma/leukemia 10 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9558 / sc-9560 / sc-55511 / sc-5611
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-BCL10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BCL10 antibody
Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. This protein contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Product Categories/Family for anti-BCL10 antibody
Applications Tested/Suitable for anti-BCL10 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-BCL10 antibody
Recommended dilution: IHC: 1:20-1:200

Immunohistochemistry (IHC) of anti-BCL10 antibody
Immunohistochemistry of paraffin-embedded human lung tissue using MBS7005827 at dilution 1:100
anti-BCL10 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-BCL10 antibody
Immunohistochemistry of paraffin-embedded human ovarian cancer using MBS7005827 at dilution 1:100
anti-BCL10 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-BCL10 antibody
Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7005827 at dilution 1:100
anti-BCL10 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for BCL10. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,252 Da
NCBI Official Full Name
B-cell lymphoma/leukemia 10
NCBI Official Synonym Full Names
B-cell CLL/lymphoma 10
NCBI Official Symbol
BCL10  [Similar Products]
NCBI Official Synonym Symbols
CLAP; mE10; CIPER; IMD37; c-E10; CARMEN
  [Similar Products]
NCBI Protein Information
B-cell lymphoma/leukemia 10
UniProt Protein Name
B-cell lymphoma/leukemia 10
UniProt Synonym Protein Names
B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10; mE10
Protein Family
UniProt Gene Name
BCL10  [Similar Products]
UniProt Synonym Gene Names
CIPER; CLAP; Bcl-10; hCLAP; CIPER; cCARMEN; c-E10; mE10  [Similar Products]
UniProt Entry Name
BCL10_HUMAN
NCBI Summary for BCL10
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]
UniProt Comments for BCL10
Bcl-10: a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer.

Protein type: Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: CBM complex; cytoplasm; cytoplasmic microtubule; cytosol; immunological synapse; lipid raft; lipopolysaccharide receptor complex; lysosome; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; T cell receptor complex

Molecular Function: enzyme binding; kinase activator activity; kinase binding; NF-kappaB binding; protease binding; protein binding; protein C-terminus binding; protein kinase B binding; protein kinase binding; protein self-association; transcription coactivator activity; transcription factor binding; ubiquitin binding; ubiquitin protein ligase binding

Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; B cell apoptosis; cell death; cellular defense response; immunoglobulin mediated immune response; innate immune response; interleukin-6 biosynthetic process; lymphotoxin A biosynthetic process; negative regulation of mature B cell apoptosis; neural tube closure; positive regulation of caspase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; positive regulation of mast cell cytokine production; positive regulation of phosphorylation; positive regulation of protein ubiquitination; positive regulation of T cell activation; positive regulation of transcription, DNA-dependent; protein heterooligomerization; protein homooligomerization; protein oligomerization; regulation of T cell receptor signaling pathway; response to food; response to fungus; response to molecule of bacterial origin; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; toll-like receptor signaling pathway

Disease: Follicular Lymphoma, Susceptibility To, 1; Gastric Lymphoma, Primary; Immunodeficiency 37; Lymphoma, Non-hodgkin, Familial; Mesothelioma, Malignant; Testicular Germ Cell Tumor
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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