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anti-BACE1 antibody :: Rabbit anti-Human BACE1 Polyclonal Antibody

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Catalog # MBS7047737
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

BACE1, Polyclonal Antibody

Popular Item
Also Known As

BACE1 Antibody

Product Synonym Names
Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2; BACE1; BACE; KIAA1149
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
376
OMIM
AF190725 mRNA
3D Structure
ModBase 3D Structure for P56817
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Beta-secretase 1 protein (46-155AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-10053 / sc-10055 / sc-10748
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-BACE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BACE1 antibody
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Applications Tested/Suitable for anti-BACE1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-BACE1 antibody
IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Immunohistochemistry (IHC) of anti-BACE1 antibody
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS7047737 at dilution of 1:100
anti-BACE1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-BACE1 antibody
Immunohistochemistry of paraffin-embedded human melanoma cancer using MBS7047737 at dilution of 1:100
anti-BACE1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-BACE1 antibody
Immunofluorescent analysis of A549 cells using MBS7047737 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-BACE1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for BACE1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,107 Da
NCBI Official Full Name
beta-secretase 1 isoform F
NCBI Official Synonym Full Names
beta-secretase 1
NCBI Official Symbol
BACE1  [Similar Products]
NCBI Official Synonym Symbols
ASP2; BACE; HSPC104
  [Similar Products]
NCBI Protein Information
beta-secretase 1
UniProt Protein Name
Beta-secretase 1
UniProt Synonym Protein Names
Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
Protein Family
UniProt Gene Name
BACE1  [Similar Products]
UniProt Synonym Gene Names
BACE; KIAA1149; ASP2; Asp 2; Beta-site APP cleaving enzyme 1  [Similar Products]
UniProt Entry Name
BACE1_HUMAN
NCBI Summary for BACE1
This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]
UniProt Comments for BACE1
BACE: an integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Cleaves APP at the amino terminus of the A-beta peptide sequence, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment which is later release by gamma-secretase. Four splice-variant isoforms have been described.

Protein type: EC 3.4.23.46; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 11q23.2-q23.3

Cellular Component: endoplasmic reticulum lumen; endosome; endosome membrane; Golgi apparatus; integral to plasma membrane; late endosome; multivesicular body; plasma membrane; trans-Golgi network

Molecular Function: aspartic-type endopeptidase activity; beta-amyloid binding; beta-aspartyl-peptidase activity; enzyme binding; peptidase activity; protein binding

Biological Process: beta-amyloid metabolic process; cellular protein metabolic process; membrane protein ectodomain proteolysis; protein catabolic process; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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