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anti-BD-2 antibody :: Goat anti-Human BD-2 Polyclonal Antibody

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Catalog # MBS691384
Unit / Price
  0.1 mg  /  $415 +1 FREE 8GB USB
anti-BD-2 antibody
Product Name

BD-2, Polyclonal Antibody

Also Known As

Goat Anti-Human BD-2

Product Synonym Names
Antigen-Affinity Purified Polyclonal Antibodies Anti-human BD-2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
64
Chromosome Location
Chromosome: 8; NC_000008.11 (7414863..7416832, complement). Location: 8p23.1
OMIM
602215
3D Structure
ModBase 3D Structure for O15263
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Purity/Purification
Affinity chromatography
Form/Format
Lyophilized
Antibody Generation
Produced from sera of goats pre-immunized with highly pure (>98%) recombinant hBD-2. Anti-hBD-2 specific antibody was purified by affinity chromatography employing immobilized hBD-2 matrix.
Buffer
PBS; pH 7.2
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-BD-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BD-2 antibody
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, six human beta-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and in some cases, a propeptide sequence. beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.
Applications Tested/Suitable for anti-BD-2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-BD-2 antibody
Western Blot: To detect hBD-2 by Western Blot analysis this antibody can be used at a concentration of 0.1- 0.2 ìg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hBD-2 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions
NCBI/Uniprot data below describe general gene information for BD-2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
Molecular Weight
7,038 Da
NCBI Official Full Name
beta-defensin 4B
NCBI Official Synonym Full Names
defensin, beta 4B
NCBI Official Symbol
DEFB4B  [Similar Products]
NCBI Official Synonym Symbols
DEFB4P
  [Similar Products]
NCBI Protein Information
beta-defensin 4B; defensin, beta 4, pseudogene
UniProt Protein Name
Beta-defensin 4A
UniProt Synonym Protein Names
Beta-defensin 2; BD-2; hBD-2; Defensin, beta 2; Skin-antimicrobial peptide 1
UniProt Gene Name
DEFB4A  [Similar Products]
UniProt Synonym Gene Names
DEFB102; DEFB2; DEFB4; BD-2; hBD-2; SAP1  [Similar Products]
UniProt Entry Name
DFB4A_HUMAN
NCBI Summary for BD-2
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]
UniProt Comments for BD-2
Function: Has antibacterial activity

Potential.

Subcellular location: Secreted.

Tissue specificity: Expressed in the skin and respiratory tract.

Induction: By inflammation.

Sequence similarities: Belongs to the beta-defensin family. LAP/TAP subfamily.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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