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anti-IBSP antibody :: Rabbit anti-Human Bone Sialoprotein Polyclonal Antibody

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Catalog # MBS315321
Unit / Price
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  0.02 mL  /  $310 +1 FREE 8GB USB
anti-IBSP antibody
Product Name

Bone Sialoprotein (IBSP), Polyclonal Antibody

Full Product Name

Rabbit anti Sialoprotein

Product Synonym Names
Rabbit Antibody to Human Bone Sialoprotein (BSP)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 4; NC_000004.11 (88720702..88733601). Location: 4q21.1
OMIM
147563
3D Structure
ModBase 3D Structure for P21815
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
Bone Sialoprotein
Human Bone Sialoprotein, rat Bone Sialoprotein. No cross reactivity with human Osteonectin or human Osteopontin.
Form/Format
Neat, Lyophilized.
Reconstitute in 20ul double distilled water.
Immunogen
Human Bone Sialoprotein (Bone extract)
Buffer
Not applicable.
Preservative
No
Lyophilized
Yes
Important Note
Vial Contains Small Quantity. Centrifuge Product Before Opening!
Preparation and Storage
Store lyophilized product at 2 to 8 degree C. After reconstitution, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-IBSP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for IBSP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
35,148 Da[Similar Products]
NCBI Official Full Name
bone sialoprotein
NCBI Official Synonym Full Names
integrin-binding sialoprotein
NCBI Official Symbol
NCBI Official Synonym Symbols
BSP; BNSP; SP-II; BSP-II
  [Similar Products]
NCBI Protein Information
bone sialoprotein 2; BSP II; OTTHUMP00000161175; bone sialoprotein II; cell-binding sialoprotein
UniProt Protein Name
Bone sialoprotein 2
UniProt Synonym Protein Names
Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
SIAL_HUMAN
NCBI Summary for IBSP
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq]
UniProt Comments for IBSP
Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Subcellular location: Secreted.

Post-translational modification: N-glycosylated; glycans consist of sialated and core-fucosylated bi-, tri- and tetraantennary chains. Ref.6O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc. Ref.6Sulfated on either Tyr-313 or Tyr-314.

Miscellaneous: It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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