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anti-CLEC4C antibody :: Rabbit anti-Human C-Type Lectin Domain Family 4 Polyclonal Antibody

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Catalog # MBS2028250 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
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  0.01 mg  /  $105 +1 FREE 8GB USB
  0.02 mg  /  $125 +1 FREE 8GB USB
  0.05 mg  /  $170 +1 FREE 8GB USB
  0.1 mg  /  $220 +1 FREE 8GB USB
  0.2 mg  /  $320 +1 FREE 8GB USB
  1 mg  /  $760 +1 FREE 8GB USB
Product Name

C-Type Lectin Domain Family 4 (CLEC4C), Polyclonal Antibody

Popular Item
Full Product Name

Polyclonal Antibody to C-Type Lectin Domain Family 4, Member C (CLEC4C)

Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- EEPQDR EKGLWWFQLK VWSMAVVSIL LLSVCFTVSS VVPHNFMYSK TVKRLSKLRE YQQYHPSLTC VMEGKDIEDW SCCPTPWTSF QSSCYFISTG MQSWTKSQKN CSVMGADLVV INTREEQDFI IQNLKRNSSY
OMIM
AF325459 mRNA
3D Structure
ModBase 3D Structure for Q8WTT0
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody is a rabbit polyclonal antibody raised against CLEC4C. It has beenselected for its ability to recognize CLEC4C in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Liquid
Concentration
200ug/ml (lot specific)
Fragment
CLEC4C (Glu5~Ile183)
Organism Species
Homo sapiens (Human)
Conjugate
No Conjugate
Immunogen
Recombinant CLEC4C (Glu5~Ile183) expressed in E Coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2058506
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-CLEC4C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CLEC4C antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-CLEC4C antibody
Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-CLEC4C antibody
Western Blot: Sample: Recombinant protein.
anti-CLEC4C antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CLEC4C antibody
DAB staining on IHC-P; Samples: Human Stomach Tissue
anti-CLEC4C antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CLEC4C antibody
DAB staining on IHC-P; Samples: Human Brain Tissue.
anti-CLEC4C antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CLEC4C antibody
DAB staining on IHC-P; Samples: Human Liver Tissue.
anti-CLEC4C antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CLEC4C antibody
DAB staining on IHC-P; Samples: Human Kidney Tissue.
anti-CLEC4C antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CLEC4C. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,498 Da
NCBI Official Full Name
C-type lectin domain family 4 member C isoform 1
NCBI Official Synonym Full Names
C-type lectin domain family 4 member C
NCBI Official Symbol
CLEC4C  [Similar Products]
NCBI Official Synonym Symbols
DLEC; HECL; BDCA2; CD303; CLECSF7; CLECSF11; PRO34150
  [Similar Products]
NCBI Protein Information
C-type lectin domain family 4 member C
UniProt Protein Name
C-type lectin domain family 4 member C
UniProt Synonym Protein Names
Blood dendritic cell antigen 2; BDCA-2; C-type lectin superfamily member 7; Dendritic lectin; CD_antigen: CD303
UniProt Gene Name
CLEC4C  [Similar Products]
UniProt Synonym Gene Names
BDCA2; CLECSF11; CLECSF7; DLEC; HECL; BDCA-2  [Similar Products]
NCBI Summary for CLEC4C
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CLEC4C
CLEC4C: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein- tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral component of membrane; plasma membrane; secretory granule membrane

Molecular Function: carbohydrate binding; metal ion binding

Biological Process: adaptive immune response; innate immune response; neutrophil degranulation; stimulatory C-type lectin receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-CLEC4C antibody
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