NP_000379.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
extracellular calcium-sensing receptor isoform 2
NCBI Official Synonym Full Names
calcium-sensing receptor
NCBI Official Synonym Symbols
CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1 [Similar Products]
NCBI Protein Information
extracellular calcium-sensing receptor
UniProt Protein Name
Extracellular calcium-sensing receptor
UniProt Synonym Protein Names
Parathyroid cell calcium-sensing receptor 1; PCaR1
UniProt Synonym Gene Names
UniProt Entry Name
CASR_HUMAN
NCBI Summary for CASR
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]
UniProt Comments for CASR
CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.
Protein type: Membrane protein, multi-pass; Motility/polarity/chemotaxis; GPCR, family 3; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q13
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; protein binding; phosphoinositide phospholipase C activity
Biological Process: cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; ossification; anatomical structure morphogenesis; metabolic process; chemosensory behavior; detection of calcium ion
Disease: Hypocalciuric Hypercalcemia, Familial, Type I; Hyperparathyroidism, Neonatal Severe; Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hypocalcemia, Autosomal Dominant 1
Research Articles on CASR
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Products associated with anti-CASR antibody
Pathways associated with anti-CASR antibody
Diseases associated with anti-CASR antibody
Organs/Tissues associated with anti-CASR antibody
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