NP_001292553.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
calmodulin isoform 1
NCBI Official Synonym Full Names
calmodulin 2 (phosphorylase kinase, delta)
NCBI Protein Information
calmodulin
UniProt Protein Name
Calmodulin
UniProt Synonym Gene Names
UniProt Entry Name
CALM_HUMAN
NCBI Summary for CALM2
This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
UniProt Comments for CALM2
Calmodulin: a calcium-binding small regulatory protein that mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Has four functional calcium-binding domains. Phosphorylation and ubiquitination result in a decreased activity.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 14q32.11
Cellular Component: centrosome; cytoplasm; cytosol; extracellular region; growth cone; nucleoplasm; nucleus; plasma membrane; sarcomere; spindle microtubule; spindle pole; vesicle
Molecular Function: adenylate cyclase binding; calcium ion binding; calcium-dependent protein binding; N-terminal myristoylation domain binding; nitric-oxide synthase binding; nitric-oxide synthase regulator activity; phosphoinositide 3-kinase binding; phospholipase binding; protein binding; protein domain specific binding; protein kinase binding; protein serine/threonine kinase activator activity; thioesterase binding; titin binding; type 3 metabotropic glutamate receptor binding
Biological Process: activation of MAPKK activity; adenylate cyclase activation; axon guidance; blood coagulation; carbohydrate metabolic process; detection of calcium ion; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; G-protein coupled receptor protein signaling pathway; glucose metabolic process; glycogen catabolic process; innate immune response; inositol phosphate metabolic process; insulin receptor signaling pathway; MAPKKK cascade; muscle contraction; nerve growth factor receptor signaling pathway; nitric oxide metabolic process; phospholipase C activation; phototransduction, visible light; platelet activation; platelet degranulation; positive regulation of cyclic nucleotide metabolic process; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of nitric-oxide synthase activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of protein amino acid dephosphorylation; Ras protein signal transduction; regulation of cytokinesis; regulation of heart rate; regulation of nitric-oxide synthase activity; regulation of rhodopsin mediated signaling; response to amphetamine; response to calcium ion; response to corticosterone stimulus; rhodopsin mediated signaling; signal transduction; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; substantia nigra development; synaptic transmission; vascular endothelial growth factor receptor signaling pathway
Disease: Long Qt Syndrome 14; Ventricular Tachycardia, Catecholaminergic Polymorphic, 4
Research Articles on CALM2
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Products associated with anti-CALM2 antibody
Pathways associated with anti-CALM2 antibody
Diseases associated with anti-CALM2 antibody
Organs/Tissues associated with anti-CALM2 antibody
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