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anti-CAPN1 antibody :: Rabbit anti-Human Calpain-1 catalytic subunit Polyclonal Antibody

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Catalog # MBS1493523
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

Calpain-1 catalytic subunit (CAPN1), Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human Calpain-1 catalytic subunit polyclonal Antibody(CAPN1)

Product Synonym Names
Calcium-activated neutral proteinase 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain; muCANP; CAPN1; CANPL1; PIG30
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
714
OMIM
114220
3D Structure
ModBase 3D Structure for P07384
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human Calpain-1 catalytic subunit protein(1-714AA)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7531 / sc-31066 / sc-31065 / sc-7530 / sc-13990
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CAPN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CAPN1 antibody
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Applications Tested/Suitable for anti-CAPN1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-CAPN1 antibody
Western blot
All lanes: CAPN1 antibody at 6ug/ml
Lane 1: A375 whole cell lysate
Lane 2: 293T whole cell lysate
Lane 3: PC-3 whole cell lysate
Lane 4: Jurkat whole cell lysate
Lane 5: Hela whole cell lysate
Lane 6: A2780 whole cell lysate
Lane 7: A431 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 82 kDa
Observed band size: 82 kDa

anti-CAPN1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CAPN1 antibody
Immunohistochemistry of paraffin-embedded human testis tissue using MBS1493523 at dilution 1:100
anti-CAPN1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CAPN1 antibody
Immunohistochemistry of paraffin-embedded human heart tissue using MBS1493523 at dilution 1:100
anti-CAPN1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CAPN1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,890 Da
NCBI Official Full Name
calpain-1 catalytic subunit
NCBI Official Synonym Full Names
calpain 1
NCBI Official Symbol
CAPN1  [Similar Products]
NCBI Official Synonym Symbols
CANP; muCL; CANP1; CANPL1; muCANP
  [Similar Products]
NCBI Protein Information
calpain-1 catalytic subunit
UniProt Protein Name
Calpain-1 catalytic subunit
UniProt Synonym Protein Names
Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain; muCANP
Protein Family
UniProt Gene Name
CAPN1  [Similar Products]
UniProt Synonym Gene Names
CANPL1; CANP 1; muCANP  [Similar Products]
UniProt Entry Name
CAN1_HUMAN
NCBI Summary for CAPN1
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Comments for CAPN1
CAPN1: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family.

Protein type: EC 3.4.22.52; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytoplasm; cytosol; focal adhesion; lysosome; membrane; mitochondrion; plasma membrane

Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; cytoskeletal protein binding; protein binding

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; mammary gland involution; positive regulation of cell proliferation; proteolysis; receptor catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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