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anti-CNR2 antibody :: Goat Cannabinoid Receptor 2 Polyclonal Antibody

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Catalog # MBS420135
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Cannabinoid Receptor 2 (CNR2), Polyclonal Antibody

Also Known As

Goat anti-Cannabinoid Receptor 2 Antibody

Product Synonym Names
CNR2; cannabinoid receptor 2 (macrophage); HGNC: 2160; CNR3; CB2; CX5; OTTHUMP00000044841; RP11-4M23.1; testis-dominant CNR2 isoform CB2; cannabinoid receptor 2 (macrophage) antibody; HGNC: 2160 antibody; CNR3 antibody; CB2 antibody; CX5 antibody; OTTHUMP00000044841 antibody; CNR2 antibody; RP11-4M23.1 antibody; testis-dominant CNR2 isoform CB2 antibody; Cannabinoid Receptor 2; Cannabinoid Receptor 2
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
360
Immunogen Sequence
TETEADGKIT PWPD
OMIM
605051
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-TETEADGKITPWPD, from the C Terminus of the protein sequence according to NP_001832.1.
Epitope
C Terminus
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CNR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CNR2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-CNR2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 40kDa band observed in Human Brain (Hippocampus) lysates (calculated MW of 46.2kDa according to NP_001832.1). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 1.5-4.5ug/ml.

Western Blot (WB) of anti-CNR2 antibody
(1.5ug/ml) staining of Human Brain (Hippocampus) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-CNR2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for CNR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,681 Da
NCBI Official Full Name
cannabinoid receptor 2
NCBI Official Synonym Full Names
cannabinoid receptor 2
NCBI Official Symbol
NCBI Official Synonym Symbols
CB2; CX5; CB-2
  [Similar Products]
NCBI Protein Information
cannabinoid receptor 2
UniProt Protein Name
Cannabinoid receptor 2
UniProt Synonym Protein Names
CX5
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CB2A; CB2B; CB-2; CB2; hCB2  [Similar Products]
UniProt Entry Name
CNR2_HUMAN
NCBI Summary for CNR2
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
UniProt Comments for CNR2
CNR2: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: dendrite; extrinsic to internal side of plasma membrane; integral to plasma membrane; perikaryon; plasma membrane

Molecular Function: cannabinoid receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; immune response; inflammatory response; negative regulation of action potential; negative regulation of inflammatory response; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; negative regulation of synaptic transmission, GABAergic; response to amphetamine; response to lipopolysaccharide; sensory perception of pain
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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