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anti-CARD14 antibody :: Rabbit anti-Human CARD14 Polyclonal Antibody

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Catalog # MBS2517739
Unit / Price
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

CARD14, Polyclonal Antibody

Popular Item
Full Product Name

CARD14 Polyclonal Antibody

Product Synonym Names
PRP; PSS1; BIMP2; CARMA2; PSORS2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
173200
3D Structure
ModBase 3D Structure for BC018142
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity purification
Concentration
1.3mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CARD14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CARD14 antibody
Background: This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.
Product Categories/Family for anti-CARD14 antibody
Applications Tested/Suitable for anti-CARD14 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CARD14 antibody
WB: 1:200-1:1000
IHC: 1:25-1:100

Western Blot (WB) of anti-CARD14 antibody
Western Blot analysis of Human fetal brain tissue using CARD14 Polyclonal Antibody at dilution of 1:650
anti-CARD14 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CARD14 antibody
Immunohistochemistry of paraffin-embedded Human liver cancer using CARD14 Polyclonal Antibody at dilution of 1:30
anti-CARD14 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CARD14 antibody
Immunohistochemistry of paraffin-embedded Human thyroid cancer using CARD14 Polyclonal Antibody at dilution of 1:30
anti-CARD14 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CARD14. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
caspase recruitment domain-containing protein 14 isoform 3
NCBI Official Synonym Full Names
caspase recruitment domain family, member 14
NCBI Official Symbol
CARD14  [Similar Products]
NCBI Official Synonym Symbols
PRP; PSS1; BIMP2; CARMA2; PSORS2
  [Similar Products]
NCBI Protein Information
caspase recruitment domain-containing protein 14; CARD-containing MAGUK protein 2; bcl10-interacting maguk protein 2
UniProt Protein Name
Caspase recruitment domain-containing protein 14
UniProt Synonym Protein Names
CARD-containing MAGUK protein 2; Carma 2
UniProt Gene Name
CARD14  [Similar Products]
UniProt Synonym Gene Names
CARMA2; Carma 2  [Similar Products]
UniProt Entry Name
CAR14_HUMAN
NCBI Summary for CARD14
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
UniProt Comments for CARD14
CARD14: a protein containing a caspase recruitment domain (CARD) that functions as an activator of BCL10 and NF-kappaB signaling. CARD is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARD proteins function as scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. The CARD domain of CARD14 associates specifically with the CARD domains of CARD10 and BCL10, a signaling protein that activates NF-kB through the IkappaB kinase complex in response to upstream stimuli. When expressed in cells, CARD14 activates NF-kappaB and induces the phosphorylation of BCL10. A subgroup of primary lymphomas of the central nervous system have higher levels of CARD14 expression.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: cytoplasm; plasma membrane

Molecular Function: CARD domain binding

Biological Process: tumor necrosis factor-mediated signaling pathway; apoptosis; activation of NF-kappaB-inducing kinase; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis; activation of NF-kappaB transcription factor

Disease: Psoriasis 2; Pityriasis Rubra Pilaris
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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