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anti-Casp1 antibody :: Rabbit anti-Human caspase-1 Polyclonal Antibody

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Catalog # MBS440006
Unit / Price
  0.2 mg  /  $240 +1 FREE 8GB USB
Western Blot (WB)
Product Name

caspase-1 (Casp1), Polyclonal Antibody

Also Known As

caspase-1 (A19) Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
3D Structure
ModBase 3D Structure for P43527
Species Reactivity
Human caspase-1 precursor (also designated ICE), non cross-reactive with caspase-1 p10 or caspase-1 p20
200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
0.200 mg/ml (lot specific)
Caspase-1 is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the amino terminus of Human caspase-1 precursor (also designated ICE).
Synthetic peptide mapping to the amino terminal domain of human caspase-2L
Preparation and Storage
Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
Other Notes
Small volumes of anti-Casp1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Casp1 antibody
Caspases is a family of mammalian proteases that regulate many of the morphological and biochemical features of apoptosis. The currently identified caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators (1,2). Caspase-2, 8, and 9 have been identified as apoptotic initiators (3,4). Caspase-2 (also designated Nedd-2/ICH-1) can be alternatively spliced to produce two distinct Caspase-2 mRNA species. One mRNA species encodes a protein of 435 amino acids in length and the mRNA splice variant encodes a 312 amino acid protein. The larger protein, Caspase-2L, in an over expressed state, leads to programmed cell death. Conversely the over expression of Caspase-2S protein, a truncated version of Caspase-2L, has been shown to suppress cell death induced by serum deprivation (5). The executioner caspases include caspase-3, 6 and 7. Of these three proteases Caspase-3 is considered to be the essential for the chromatin margination, DNA fragmentation, and nuclear collapse during apoptosis (6). Caspase-1 (also known as ICE) is considered to be a mediator of the inflammatory response by converting the inactive precursor of interleukin-1b to the 17 kDa proinflammatory cytokine, IL-1b (7,8).
Applications Tested/Suitable for anti-Casp1 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

Western Blot (WB) of anti-Casp1 antibody
anti-Casp1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for Casp1. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
45,576 Da[Similar Products]
NCBI Official Full Name
NCBI Official Synonym Full Names
caspase 1
NCBI Official Symbol
Casp1  [Similar Products]
NCBI Official Synonym Symbols
Ice; Il1bc
  [Similar Products]
NCBI Protein Information
caspase-1; CASP-1; IL-1 beta-converting enzyme; IL-1BC; Interleukin 1beta converting enzyme; interleukin 1, beta, convertase; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45
UniProt Protein Name
UniProt Synonym Protein Names
Interleukin-1 beta convertase; IL-1BC
Protein Family
UniProt Gene Name
Casp1  [Similar Products]
UniProt Synonym Gene Names
Il1bc; Il1bce; CASP-1; IL-1BC; ICE; IL-1 beta-converting enzyme  [Similar Products]
UniProt Entry Name
NCBI Summary for Casp1
apoptotic protease that may play a role in inflammation and apoptosis in male sex organs [RGD, Feb 2006]
UniProt Comments for Casp1
CASP1: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity)

Protein type: EC; Protease; Apoptosis
Product References and Citations for anti-Casp1 antibody
1. Edadah BA, Faden AI. 2000. Caspase pathways, neuronal apoptosis, and CNS injury. Jounal of Neurotauma 17(10): 811-8292. Salvesen GS, Dixit VM. 1999. Caspase activation: the induced-proximity model. Proc Natl Acad Sci USA 96(20): 10964-109673. Zhang W, He Q, Chan LL, Zhou F, El Naghy M, Thompson EB, Ansari NH. 2001. Involvment of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells. Free Radic Biol Med 30(6): 699-7064. Kruidering M, Evan GI. 2000. Caspase-8 in apoptosis: the beginning of ?the end? ? IUBMB 50(2): 85-905. Wang L, Miura M, Bergeron L, Zhu H, Yuan J. 1994. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78(5): 739-7506. Slee EA, Adrain C, Martin SJ. 2001. Executioner caspase-3, -6, and ?7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 276(10): 7320-73267. Kostura MJ, Tocci MJ, Limjuco G, Chin J, Cameron P, Hillman AG, Chartrain NA, Schmidt JA. 1989. Identification of a monocyte specific pre-interleukin 1b convertase activity. Proc Natl Acad Sci USA 86(14): 5227-52318. Wilson KP, Black JA, Thompson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, Livingston DJ. 1994. Structure and mechanism of interleukin-1b converting enzyme. Nature 370(6487): 251-252

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