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anti-Casp1 antibody :: Rabbit anti-Human caspase-1 Polyclonal Antibody

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Catalog # MBS440006
Unit / Price
  0.2 mg  /  $240 +1 FREE 8GB USB
Western Blot (WB)
Product Name

caspase-1 (Casp1), Polyclonal Antibody

Also Known As

caspase-1 (A19) Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
402
3D Structure
ModBase 3D Structure for P43527
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
Human caspase-1 precursor (also designated ICE), non cross-reactive with caspase-1 p10 or caspase-1 p20
Form/Format
200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
Concentration
0.200 mg/ml (lot specific)
Origin
Caspase-1 is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the amino terminus of Human caspase-1 precursor (also designated ICE).
Immunogen
Synthetic peptide mapping to the amino terminal domain of human caspase-2L
Preparation and Storage
Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
Other Notes
Small volumes of anti-Casp1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Casp1 antibody
Caspases is a family of mammalian proteases that regulate many of the morphological and biochemical features of apoptosis. The currently identified caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators (1,2). Caspase-2, 8, and 9 have been identified as apoptotic initiators (3,4). Caspase-2 (also designated Nedd-2/ICH-1) can be alternatively spliced to produce two distinct Caspase-2 mRNA species. One mRNA species encodes a protein of 435 amino acids in length and the mRNA splice variant encodes a 312 amino acid protein. The larger protein, Caspase-2L, in an over expressed state, leads to programmed cell death. Conversely the over expression of Caspase-2S protein, a truncated version of Caspase-2L, has been shown to suppress cell death induced by serum deprivation (5). The executioner caspases include caspase-3, 6 and 7. Of these three proteases Caspase-3 is considered to be the essential for the chromatin margination, DNA fragmentation, and nuclear collapse during apoptosis (6). Caspase-1 (also known as ICE) is considered to be a mediator of the inflammatory response by converting the inactive precursor of interleukin-1b to the 17 kDa proinflammatory cytokine, IL-1b (7,8).
Applications Tested/Suitable for anti-Casp1 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

Western Blot (WB) of anti-Casp1 antibody
anti-Casp1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for Casp1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
45,576 Da[Similar Products]
NCBI Official Full Name
caspase-1
NCBI Official Synonym Full Names
caspase 1
NCBI Official Symbol
Casp1  [Similar Products]
NCBI Official Synonym Symbols
Ice; Il1bc
  [Similar Products]
NCBI Protein Information
caspase-1; CASP-1; IL-1 beta-converting enzyme; IL-1BC; Interleukin 1beta converting enzyme; interleukin 1, beta, convertase; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45
UniProt Protein Name
Caspase-1
UniProt Synonym Protein Names
Interleukin-1 beta convertase; IL-1BC
Protein Family
UniProt Gene Name
Casp1  [Similar Products]
UniProt Synonym Gene Names
Il1bc; Il1bce; CASP-1; IL-1BC; ICE; IL-1 beta-converting enzyme  [Similar Products]
UniProt Entry Name
CASP1_RAT
NCBI Summary for Casp1
apoptotic protease that may play a role in inflammation and apoptosis in male sex organs [RGD, Feb 2006]
UniProt Comments for Casp1
CASP1: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity)

Protein type: EC 3.4.22.36; Protease; Apoptosis
Product References and Citations for anti-Casp1 antibody
1. Edadah BA, Faden AI. 2000. Caspase pathways, neuronal apoptosis, and CNS injury. Jounal of Neurotauma 17(10): 811-8292. Salvesen GS, Dixit VM. 1999. Caspase activation: the induced-proximity model. Proc Natl Acad Sci USA 96(20): 10964-109673. Zhang W, He Q, Chan LL, Zhou F, El Naghy M, Thompson EB, Ansari NH. 2001. Involvment of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells. Free Radic Biol Med 30(6): 699-7064. Kruidering M, Evan GI. 2000. Caspase-8 in apoptosis: the beginning of ?the end? ? IUBMB 50(2): 85-905. Wang L, Miura M, Bergeron L, Zhu H, Yuan J. 1994. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78(5): 739-7506. Slee EA, Adrain C, Martin SJ. 2001. Executioner caspase-3, -6, and ?7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 276(10): 7320-73267. Kostura MJ, Tocci MJ, Limjuco G, Chin J, Cameron P, Hillman AG, Chartrain NA, Schmidt JA. 1989. Identification of a monocyte specific pre-interleukin 1b convertase activity. Proc Natl Acad Sci USA 86(14): 5227-52318. Wilson KP, Black JA, Thompson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, Livingston DJ. 1994. Structure and mechanism of interleukin-1b converting enzyme. Nature 370(6487): 251-252

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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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