NP_001217.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,574 Da
NCBI Official Full Name
caspase-6 isoform alpha
NCBI Official Synonym Full Names
caspase 6
NCBI Official Synonym Symbols
NCBI Protein Information
caspase-6
UniProt Protein Name
Caspase-6
UniProt Synonym Protein Names
Apoptotic protease Mch-2
UniProt Synonym Gene Names
NCBI Summary for CASP6
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]
UniProt Comments for CASP6
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Product References and Citations for anti-CASP6 antibody
(1) Lee, S.Y., Choi, Y.Y., Choi, J.E., et al. Polymorphisms in the caspase genes and the risk of lung cancer. J Thorac Oncol 5 (8), 1152-1158 (2010).
Research Articles on CASP6
Precautions
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Disclaimer
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Products associated with anti-CASP6 antibody
Pathways associated with anti-CASP6 antibody
Diseases associated with anti-CASP6 antibody
Organs/Tissues associated with anti-CASP6 antibody
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