• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-COMT antibody :: Rabbit anti-Human Catechol O-methyltransferase Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS1489377
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Immunofluorescence (IF)
Product Name

Catechol O-methyltransferase (COMT), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human Catechol O-methyltransferase polyclonal Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
611451
3D Structure
ModBase 3D Structure for Q8WZ04
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human Catechol O-methyltransferase
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-COMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-COMT antibody
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Applications Tested/Suitable for anti-COMT antibody
ELISA (EIA), Immunofluorescence (IF)

Immunofluorescence (IF) of anti-COMT antibody
Immunofluorescent analysis of HepG2 cells using MBS1489377 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-COMT antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for COMT. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,548 Da
NCBI Official Full Name
transmembrane O-methyltransferase isoform LRTOMT2a
NCBI Official Synonym Full Names
leucine rich transmembrane and O-methyltransferase domain containing
NCBI Official Symbol
LRTOMT  [Similar Products]
NCBI Official Synonym Symbols
DFNB63; LRRC51; CFAP111
  [Similar Products]
NCBI Protein Information
leucine-rich repeat-containing protein 51; transmembrane O-methyltransferase
UniProt Protein Name
Transmembrane O-methyltransferase
UniProt Synonym Protein Names
Catechol O-methyltransferase 2
UniProt Gene Name
LRTOMT  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
TOMT_HUMAN
NCBI Summary for COMT
This gene includes two transcript forms. The short form has one open reading frame (ORF), which encodes the leucine-rich repeats (LRR)-containing protein of unknown function. This protein is called LRTOMT1 or LRRC51. The long form has two alternative ORFs; the upstream ORF has the same translation start codon as used in the short form and the resulting transcript is a candidate for nonsense-mediated decay, and the downstream ORF encodes a different protein, which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory and vestibular function. Defects in the COMT2 can cause nonsyndromic deafness. Alternatively spliced transcript variants from each transcript form have been found for this gene. [provided by RefSeq, Sep 2012]
UniProt Comments for COMT
LRTOMT: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function. Defects in LRTOMT are the cause of deafness autosomal recessive type 63 (DFNB63). A form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the methyltransferase superfamily. Catechol-O-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; Cell development/differentiation; Membrane protein, integral; EC 2.1.1.6

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: cytoplasm; integral to membrane

Molecular Function: catechol O-methyltransferase activity

Biological Process: auditory receptor cell development; catecholamine catabolic process; methylation; neurotransmitter catabolic process; sensory perception of sound

Disease: Deafness, Autosomal Recessive 63
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-COMT antibody
 Reference Product  PubMed Publications
 TMC1 antibody  >2 publications with COMT and TMC1
Pathways associated with anti-COMT antibody
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000