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anti-CTSC antibody :: Rabbit anti-Human Cathepsin C Polyclonal Antibody

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Catalog # MBS2536107
Unit / Price
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  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Cathepsin C (CTSC), Polyclonal Antibody

Full Product Name

Cleaved-Cathepsin C HC (R394) Polyclonal Antibody

Product Synonym Names
CTSC; CPPI; Dipeptidyl peptidase 1; Cathepsin C; Cathepsin J; Dipeptidyl peptidase I; DPP-I; DPPI; Dipeptidyl transferase
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
170650
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the C-terminal region of human Cathepsin C HC.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CTSC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CTSC antibody
Applications Tested/Suitable for anti-CTSC antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CTSC antibody
WB: 1:500-1:2000, ELISA: 1:5000-1:20000

Western Blot (WB) of anti-CTSC antibody
Western Blot analysis of various cells with Cleaved-Cathepsin C HC (R394) Polyclonal Antibody.
anti-CTSC antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for CTSC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 52
Observed MW: 27[Similar Products]
NCBI Official Full Name
cathepsin C
NCBI Official Synonym Full Names
cathepsin C
NCBI Official Symbol
NCBI Official Synonym Symbols
JP; HMS; JPD; PLS; CPPI; DPP1; DPPI; PALS; DPP-I; PDON1
  [Similar Products]
NCBI Protein Information
dipeptidyl peptidase 1
UniProt Protein Name
Dipeptidyl peptidase 1
UniProt Synonym Protein Names
Cathepsin C; Cathepsin J; Dipeptidyl peptidase I; DPP-I; DPPI
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CPPI; DPP-I; DPPI  [Similar Products]
UniProt Entry Name
CATC_HUMAN
NCBI Summary for CTSC
This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015]
UniProt Comments for CTSC
CTSC: Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. Defects in CTSC are a cause of Papillon-Lefevre syndrome (PLS); also known as keratosis palmoplantaris with periodontopathia. PLS is an autosomal recessive disorder characterized by palmoplantar keratosis and severe periodontitis affecting deciduous and permanent dentitions and resulting in premature tooth loss. The palmoplantar keratotic phenotype vary from mild psoriasiform scaly skin to overt hyperkeratosis. Keratosis also affects other sites such as elbows and knees. Defects in CTSC are a cause of Haim-Munk syndrome (HMS); also known as keratosis palmoplantaris with periodontopathia and onychogryposis or Cochin Jewish disorder. HMS is an autosomal recessive disorder characterized by palmoplantar keratosis, onychogryphosis and periodontitis. Additional features are pes planus, arachnodactyly, and acroosteolysis. Defects in CTSC are a cause of aggressive periodontititis type 1 (AP1); also known as juvenile periodontitis (JPD) and prepubertal periodontitis (PPP). AP1 is characterized by severe and protracted gingival infections, leading to tooth loss. AP1 inheritance is autosomal dominant. Belongs to the peptidase C1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; EC 3.4.14.1; Protease

Chromosomal Location of Human Ortholog: 11q14.2

Cellular Component: endoplasmic reticulum lumen; ER to Golgi transport vesicle; ER-Golgi intermediate compartment membrane; extracellular space; Golgi membrane; lysosome; membrane

Molecular Function: apoptotic protease activator activity; chaperone binding; chloride ion binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; identical protein binding; phosphatase binding; protein binding; protein self-association; serine-type endopeptidase activity

Biological Process: aging; apoptosis; cellular protein metabolic process; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; immune response; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; proteolysis; proteolysis involved in cellular protein catabolic process; response to organic substance; T cell mediated cytotoxicity

Disease: Haim-munk Syndrome; Papillon-lefevre Syndrome; Periodontitis, Aggressive, 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-CTSC antibody
 Reference Product  PubMed Publications
 CTSL1 antibody  >1 publications with CTSC and CTSL1
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