NP_065396.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,678 Da
NCBI Official Full Name
killer cell immunoglobulin-like receptor 2DL5A
NCBI Official Synonym Full Names
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A
NCBI Official Synonym Symbols
CD158F; KIR2DL5; KIR2DL5.1; KIR2DL5.3 [Similar Products]
NCBI Protein Information
killer cell immunoglobulin-like receptor 2DL5A
UniProt Protein Name
Killer cell immunoglobulin-like receptor 2DL5A
UniProt Synonym Protein Names
CD_antigen: CD158f1
UniProt Synonym Gene Names
NCBI Summary for CD158f1/2
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
UniProt Comments for CD158f1/2
Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
Research Articles on CD158f1/2
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Products associated with anti-CD158f1/2 antibody
Pathways associated with anti-CD158f1/2 antibody
Diseases associated with anti-CD158f1/2 antibody
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