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anti-CD2 antibody :: Rabbit anti-Human CD2 Polyclonal Antibody

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Catalog # MBS9407467
Unit / Price
  0.1 mL  /  $320 +1 FREE 8GB USB
Testing Data
Product Name

CD2, Polyclonal Antibody

Full Product Name

CD2 Antibody

Product Synonym Names
FLJ46032 antibody; SRBC antibody; T11 antibody; CD2 antibody; erythrocyte receptor antibody; LFA-2 antibody; "CD2 antigen (p50); sheep red blood cell receptor antibody"; rosette receptor antibody; lymphocyte-function antigen-2 antibody; LFA-3 receptor ant
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
186990
3D Structure
ModBase 3D Structure for P06729
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody detects endogenous levels of total CD2 protein.
Purity/Purification
Antibodies were purified by antigen-affinity chromatography.
Form/Format
Rabbit IgG in 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration
1 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant fragment corresponding to a region within amino acids 1 and 225 of CD2.
Target Name
CD2
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-CD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD2 antibody
CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM]
Product Categories/Family for anti-CD2 antibody
Applications Tested/Suitable for anti-CD2 antibody
Western Blot (WB)
Application Notes for anti-CD2 antibody
Western blotting: 1:500-1:3000

Testing Data of anti-CD2 antibody
Sample (30 ug of whole cell lysate) A: K562 B: THP-1 10% SDS PAGE diluted at 1:1000
anti-CD2 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for CD2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,448 Da
NCBI Official Full Name
T-cell surface antigen CD2
NCBI Official Synonym Full Names
CD2 molecule
NCBI Official Symbol
NCBI Official Synonym Symbols
T11; SRBC; LFA-2
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NCBI Protein Information
T-cell surface antigen CD2
UniProt Protein Name
T-cell surface antigen CD2
UniProt Synonym Protein Names
Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
CD2_HUMAN
NCBI Summary for CD2
CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
UniProt Comments for CD2
CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.

Protein type: Membrane protein, integral; Cell surface; Apoptosis

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: internal side of plasma membrane; cell surface; anchored to plasma membrane; integral to plasma membrane; extracellular region; plasma membrane; intercellular junction; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: heterotypic cell-cell adhesion; cell-cell adhesion; cell surface receptor linked signal transduction; T cell activation; apoptosis; natural killer cell activation; regulation of T cell differentiation; positive regulation of tumor necrosis factor production; lipid raft polarization; blood coagulation; leukocyte migration; positive regulation of myeloid dendritic cell activation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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