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anti-CD6 antibody :: Rabbit anti-Human CD6 Polyclonal Antibody

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Catalog # MBS1496211
Unit / Price
  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

CD6, Polyclonal Antibody

Popular Item
Also Known As

Rabbit anti-human CD6 polyclonal Antibody

Product Synonym Names
T12; TP120; CD6
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
601
OMIM
186720
3D Structure
ModBase 3D Structure for P30203
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human T-cell differentiation antigen CD6 protein (424-668aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-15910 / sc-7074 / sc-20921
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CD6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD6 antibody
Involved in cell adhesion. Binds to CD166.
Applications Tested/Suitable for anti-CD6 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CD6 antibody
Recommended dilution: WB:1:500-2000
IHC:1:20-1:200

Western Blot (WB) of anti-CD6 antibody
All lanes: CD6 antibody at 4ug/ml
Lane 1:Hela whole cell lysate
Lane 2:jurkat whole cell lysate
Lane 3:HT-29 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 72,69,64,65,59,61 kDa
Observed band size: 72 kDa

anti-CD6 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CD6 antibody
Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS1496211 at dilution 1:100
anti-CD6 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CD6 antibody
Immunohistochemistry of paraffin-embedded human thymus using MBS1496211 at dilution 1:100
anti-CD6 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CD6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,572 Da
NCBI Official Full Name
T-cell differentiation antigen CD6 isoform 2
NCBI Official Synonym Full Names
CD6 molecule
NCBI Official Symbol
NCBI Official Synonym Symbols
TP120
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NCBI Protein Information
T-cell differentiation antigen CD6
UniProt Protein Name
T-cell differentiation antigen CD6
UniProt Synonym Protein Names
T12; TP120; CD_antigen: CD6
Protein Family
UniProt Gene Name
UniProt Entry Name
CD6_HUMAN
NCBI Summary for CD6
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for CD6
CD6: a type I membrane protein involved in cell adhesion. Binds to CD166. Expressed on thymocytes, peripheral T cells, a subset of B cells, and a subset of neurons. Mediates the binding of developing thymocytes with thymic epithelial cells. CD6- T cells are less autoreactive than CD6+ T cells. Phosphorylated on tyrosines and serines following T cell antigen receptor signaling. Five splice-variant isoforms have been described.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular region; immunological synapse; integral to plasma membrane; intrinsic to plasma membrane; T cell receptor complex

Molecular Function: lipopolysaccharide binding; protein binding; scavenger receptor activity

Biological Process: acute inflammatory response to antigenic stimulus; adaptive immune response; formation of immunological synapse; heterophilic cell adhesion; innate immune response; lipopolysaccharide-mediated signaling pathway; positive regulation of T cell proliferation; receptor-mediated endocytosis; response to lipopolysaccharide
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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