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anti-CD80 antibody :: Rabbit anti-Human CD80 Polyclonal Antibody

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Catalog # MBS9202324
Unit / Price
  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Product Name

CD80, Polyclonal Antibody

Popular Item
Also Known As

CD80 Antibody (C-term)

Product Synonym Names
T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B71; B7; CD80; CD80; CD28LG; CD28LG1; LAB7
Antibody/Peptide Pairs
CD80 peptide (MBS9225475) is used for blocking the activity of CD80 antibody (MBS9202324)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
260-288
Immunogen Sequence Length
162
OMIM
112203
3D Structure
ModBase 3D Structure for P33681
Clonality
Polyclonal
Isotype
Rabbit Ig
Clone Number
RB22396
Host
Rabbit
Species Reactivity
Human
Specificity
This CD80 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-288 amino acids from the C-terminal region of human CD80.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation
Cellular location
Membrane; Single-pass type I membrane protein
Tissue location
Expressed on activated B-cells, macrophages and dendritic cells
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-CD80 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD80 antibody
CD80 is activation antigen B7-1 (formerly referred to as B7) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 (MIM 186760) and CTLA4 (MIM 123890) ligands of T cells.
Applications Tested/Suitable for anti-CD80 antibody
FC,E
Application Notes for anti-CD80 antibody
FC~~1:10~50

Western Blot (WB) of anti-CD80 antibody
Western blot analysis of CD80 Antibody (C-term) in HL-60 cell line lysates (35ug/lane).CD80 (arrow) was detected using the purified Pab.
anti-CD80 antibody Western Blot (WB) (WB) image
Flow Cytometry (FC/FACS) of anti-CD80 antibody
CD80 Antibody (C-term) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-CD80 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
NCBI/Uniprot data below describe general gene information for CD80. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
T-lymphocyte activation antigen CD80
NCBI Official Synonym Full Names
CD80 molecule
NCBI Official Symbol
NCBI Official Synonym Symbols
B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1
  [Similar Products]
NCBI Protein Information
T-lymphocyte activation antigen CD80
UniProt Protein Name
T-lymphocyte activation antigen CD80
UniProt Synonym Protein Names
Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD_antigen: CD80
UniProt Gene Name
UniProt Synonym Gene Names
CD28LG; CD28LG1; LAB7; B7  [Similar Products]
UniProt Entry Name
CD80_HUMAN
NCBI Summary for CD80
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
UniProt Comments for CD80
CD80: Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 3q13.3-q21

Cellular Component: cell surface; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; coreceptor activity

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of signal transduction; viral reproduction; nerve growth factor receptor signaling pathway; T cell activation; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-2 biosynthetic process; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; T cell costimulation; innate immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of T-helper 1 cell differentiation
Product References and Citations for anti-CD80 antibody
Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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