NP_001171482.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cell division control protein 45 homolog isoform 3
NCBI Official Synonym Full Names
cell division cycle 45
NCBI Protein Information
cell division control protein 45 homolog; human CDC45; CDC45-related protein; cell division cycle 45-like 2; cell division cycle 45 homolog; CDC45 cell division cycle 45 homolog
UniProt Protein Name
Cell division control protein 45 homolog
UniProt Synonym Protein Names
PORC-PI-1
UniProt Synonym Gene Names
UniProt Entry Name
CDC45_HUMAN
NCBI Summary for CDC45
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for CDC45
CDC45L: Required for initiation of chromosomal DNA replication. Associated with ORC2. Widely expressed, highest levels are found in adult testis and thymus and in fetal liver. Belongs to the CDC45 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: nucleoplasm; centrosome; cytoplasm; nucleus
Molecular Function: protein binding; 3'-5' DNA helicase activity; DNA replication origin binding; chromatin binding; single-stranded DNA binding
Biological Process: G1/S-specific transcription in mitotic cell cycle; DNA replication initiation; regulation of chromatin silencing at telomere; DNA strand elongation during DNA replication; mitotic cell cycle; DNA replication checkpoint; DNA replication; DNA duplex unwinding; double-strand break repair via break-induced replication; pre-replicative complex assembly; G1/S transition of mitotic cell cycle
Research Articles on CDC45
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Pathways associated with anti-CDC45 antibody
Diseases associated with anti-CDC45 antibody
Organs/Tissues associated with anti-CDC45 antibody
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