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anti-Cdc6 antibody :: Rabbit anti-Human Cdc6 Polyclonal Antibody

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Catalog # MBS4750650
Unit / Price
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  0.1 mL  /  $335 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Cdc6, Polyclonal Antibody

Full Product Name

Anti-Phospho-Cdc6 (S54) Rabbit pAb

Product Synonym Names
CDC6; CDC18L; CDC6-related protein; Cdc18-related protein; HsCDC6; HsCDC18; p62(cdc6)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
602627
3D Structure
ModBase 3D Structure for Q99741
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
Phospho-Cdc6 (S54) Antibody detects endogenous levels of total Phospho-Cdc6 (S54)
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human Phospho-Cdc6 (S54)
Subcellular Location
Cytoplasm
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-Cdc6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Cdc6 antibody
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.Cdc6 has recently been shown to play an important role in the intra-S-phase p21 Waf1/Cip1-dependent DNA damage response. Both cdc6 and CDT1 are degraded by the ubiquitin proteasome pathway in response to DNA damage associated with re-replication.
Applications Tested/Suitable for anti-Cdc6 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-Cdc6 antibody
WB: 1:500-1:1000
ICC/IF: 1:50-1:200

Western Blot (WB) of anti-Cdc6 antibody
Western blot analysis of Phospho-Cdc6 (S54) expression in (1) Raji cell lysate; (2) Raji + FBS cell lysate.
anti-Cdc6 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for Cdc6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63kDa
NCBI Official Full Name
cell division control protein 6 homolog
NCBI Official Synonym Full Names
cell division cycle 6
NCBI Official Symbol
NCBI Official Synonym Symbols
CDC18L; HsCDC6; MGORS5; HsCDC18
  [Similar Products]
NCBI Protein Information
cell division control protein 6 homolog
UniProt Protein Name
Cell division control protein 6 homolog
UniProt Synonym Protein Names
CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6
UniProt Gene Name
UniProt Synonym Gene Names
CDC18L; HsCdc18; HsCDC6  [Similar Products]
NCBI Summary for Cdc6
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for Cdc6
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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