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anti-CDC6 antibody :: Rabbit anti-Human CDC6 Polyclonal Antibody

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Catalog # MBS7051040
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

CDC6, Polyclonal Antibody

Popular Item
Full Product Name

CDC6 Antibody

Product Synonym Names
Cell division control protein 6 homolog; CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6; CDC6; CDC18L
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
U77949 mRNA
3D Structure
ModBase 3D Structure for Q99741
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Cell division control protein 6 homolog protein (1-141AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-32507 / sc-8341
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CDC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CDC6 antibody
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Applications Tested/Suitable for anti-CDC6 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CDC6 antibody
WB: 1: 500-1: 5000
IHC: 1: 20-1: 200

Western Blot (WB) of anti-CDC6 antibody
Western Blot
Positive WB detected in: HepG2 whole cell lysate,Jurkat whole cell lysate,RAW264.7 whole cell lysate,Raji whole cell lysate
All lanes: CDC6 antibody at 2.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 63 KDa
Observed band size: 63 KDa

anti-CDC6 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CDC6 antibody
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS7051040 at dilution of 1:100
anti-CDC6 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CDC6 antibody
Immunohistochemistry of paraffin-embedded human ovarian cancer using MBS7051040 at dilution of 1:100
anti-CDC6 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CDC6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,720 Da
NCBI Official Full Name
cell division control protein 6 homolog
NCBI Official Synonym Full Names
cell division cycle 6
NCBI Official Symbol
NCBI Official Synonym Symbols
CDC18L; HsCDC6; MGORS5; HsCDC18
  [Similar Products]
NCBI Protein Information
cell division control protein 6 homolog
UniProt Protein Name
Cell division control protein 6 homolog
UniProt Synonym Protein Names
CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6
UniProt Gene Name
UniProt Synonym Gene Names
CDC18L; HsCdc18; HsCDC6  [Similar Products]
UniProt Entry Name
CDC6_HUMAN
NCBI Summary for CDC6
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for CDC6
CDC6: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Belongs to the CDC6/cdc18 family.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus; spindle midzone; spindle pole

Molecular Function: kinase binding; nucleotide binding; protein binding

Biological Process: DNA replication; DNA replication checkpoint; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; negative regulation of DNA replication; positive regulation of chromosome segregation; positive regulation of cytokinesis; regulation of cyclin-dependent protein kinase activity; regulation of mitotic metaphase/anaphase transition; traversing start control point of mitotic cell cycle

Disease: Meier-gorlin Syndrome 5
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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