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anti-CDSN antibody :: Rabbit anti-Human CDSN Polyclonal Antibody

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Catalog # MBS7046195
Unit / Price
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  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

CDSN, Polyclonal Antibody

Popular Item
Full Product Name

CDSN Antibody

Product Synonym Names
Corneodesmosin; S protein; CDSN
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
146520
3D Structure
ModBase 3D Structure for Q15517
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Species
Human
Immunogen
Recombinant human Corneodesmosin protein
Conjugate
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49616 / sc-49620 / sc-49621
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CDSN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CDSN antibody
Important for the epidermal barrier integrity.
Applications Tested/Suitable for anti-CDSN antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunohistochemistry (IHC) of anti-CDSN antibody
Immunohistochemistry of paraffin-embedded human lymphoid tissue using MBS7046195 at dilution of 1:100
anti-CDSN antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-CDSN antibody
Western Blot
Positive WB detected in:mouse liver tissue,mouse spleen tissue,mouse kidney tissue,MCF7 whole cell lysate
All lanes: CDSN antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52 kDa
Observed band size: 52,34 kDa

anti-CDSN antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-CDSN antibody
Immunofluorescent analysis of HepG2 cells using MBS7046195 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-CDSN antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CDSN. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,522 Da
NCBI Official Full Name
corneodesmosin
NCBI Official Synonym Full Names
corneodesmosin
NCBI Official Symbol
NCBI Official Synonym Symbols
S; PSS; HTSS; PSS1; HTSS1; HYPT2
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NCBI Protein Information
corneodesmosin
UniProt Protein Name
Corneodesmosin
UniProt Synonym Protein Names
S protein
Protein Family
UniProt Gene Name
UniProt Entry Name
CDSN_HUMAN
NCBI Summary for CDSN
This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Dec 2014]
UniProt Comments for CDSN
CDSN: Important for the epidermal barrier integrity. Defects in CDSN are the cause of hypotrichosis type 2 (HYPT2). A condition characterized by the presence of less than the normal amount of hair. Affected individuals have normal hair in early childhood but experience progressive hair loss limited to the scalp beginning in the middle of the first decade and almost complete baldness by the third decade. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. Defects in CDSN are a cause of peeling skin syndrome (PSS); also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. A genodermatosis characterized by generalized, continuous shedding of the outer layers of the epidermis. Two main PSS subtypes have been suggested. Patients with non-inflammatory PSS (type A) manifest white scaling, with painless and easy removal of the skin, irritation when in contact with water, dust and sand, and no history of erythema, pruritis or atopy. Inflammatory PSS (type B) is associated with generalized erythema, pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly after. Several patients have been reported with high IgE levels. CDNS mutations are responsible for generalized, inflammatory peeling skin syndrome type B (PubMed:20691404).

Protein type: Secreted; Cell adhesion; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cornified envelope; desmosome; intercellular junction

Molecular Function: protein homodimerization activity

Biological Process: cell adhesion; cell-cell adhesion; epidermis development; skin morphogenesis

Disease: Hypotrichosis 2; Peeling Skin Syndrome 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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