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anti-CELA3B antibody :: Rabbit anti-Human CELA3B Polyclonal Antibody

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Catalog # MBS6005083
Unit / Price
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  0.2 mL  /  $610 +1 FREE 8GB USB
Product Name

CELA3B, Polyclonal Antibody

Popular Item
Full Product Name

CELA3B, NT (CELA3B, ELA3B, Chymotrypsin-like elastase family member 3B, Elastase IIIB, Elastase-3B, Protease E)

Product Synonym Names
Anti -CELA3B, NT (CELA3B, ELA3B, Chymotrypsin-like elastase family member 3B, Elastase IIIB, Elastase-3B, Protease E)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (22303418..22315847). Location: 1p36.12
3D Structure
ModBase 3D Structure for P08861
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
Recognizes human CELA3B.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Concentration
0.51mg/ml (lot specific)
Immunogen
Synthetic peptide corresponding to aa70-98 from the N-terminal region of human CELA3B, conjugated to KLH (NP_031378.1)
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-CELA3B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CELA3B antibody
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
Product Categories/Family for anti-CELA3B antibody
Applications Tested/Suitable for anti-CELA3B antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CELA3B antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:1000
Immunohistochemistry: 1:10-1:50
Optimal dilutions to be determined by the researcher.

Western Blot of anti-CELA3B antibody
Western Blot analysis of MBS6005083 in NCI-H460 cell line Iysates (35ug/lane).This demonstrates the CElA3B antibody detected the CElA3B protein (arrow).
anti-CELA3B antibody Western Blot (WB) image
Immunohistochemistry of anti-CELA3B antibody
Immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue using MBS6005083 followed by peroxidase conjugation of the secondary antibody and DAB staining.
anti-CELA3B antibody Immunohistochemistry (IHC) image
NCBI/Uniprot data below describe general gene information for CELA3B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,263 Da[Similar Products]
NCBI Official Full Name
Chymotrypsin-like elastase family member 3B
NCBI Official Synonym Full Names
chymotrypsin-like elastase family, member 3B
NCBI Official Symbol
CELA3B  [Similar Products]
NCBI Official Synonym Symbols
E1; CBPP; EL-1; ELA3B
  [Similar Products]
NCBI Protein Information
chymotrypsin-like elastase family member 3B; elastase 1; protease E; elastase-3B; proteinase E; elastase IIIB; fecal elastase 1; pancreatic elastase 1; elastase 3B, pancreatic; pancreatic endopeptidase E; cholesterol-binding pancreatic protease
UniProt Protein Name
Chymotrypsin-like elastase family member 3B
UniProt Synonym Protein Names
Elastase IIIB; Elastase-3B; Protease E
UniProt Gene Name
CELA3B  [Similar Products]
UniProt Synonym Gene Names
ELA3B  [Similar Products]
UniProt Entry Name
CEL3B_HUMAN
NCBI Summary for CELA3B
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]
UniProt Comments for CELA3B
CELA3B: Efficient protease with alanine specificity but only little elastolytic activity. Belongs to the peptidase S1 family. Elastase subfamily.

Protein type: EC 3.4.21.70; Protease

Chromosomal Location of Human Ortholog: 1p36.12

Molecular Function: peptidase activity; serine-type endopeptidase activity

Biological Process: cholesterol metabolic process; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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