EAW90210.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
centaurin, beta 1, isoform CRA_b
NCBI Official Synonym Full Names
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
NCBI Official Synonym Symbols
NCBI Protein Information
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
UniProt Protein Name
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
UniProt Synonym Protein Names
Centaurin-beta-1; Cnt-b1
UniProt Synonym Gene Names
UniProt Entry Name
ACAP1_HUMAN
UniProt Comments for ACAP1
CENTB1: a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins (GAPs). A GAP for ARF1 and ARF5. Two alternatively-spliced isoforms have been described. Isoform 1 is brain-specific, and isoform 2 is ubiquitously expressed, with highest levels in brain and heart. Isoform 1 participates to the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. Regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. The PH domains of isoforms 1 and 2 bind phospholipids, but they differentially regulate subcellular location. The PH domain of isoform 1 directs the protein to the nucleus, but the PH domain of isoform 2 directs it to the cytosol.
Protein type: Motility/polarity/chemotaxis; GAPs; GAPs, ARF
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: membrane; recycling endosome membrane
Molecular Function: zinc ion binding
Biological Process: protein transport; positive regulation of GTPase activity
Research Articles on ACAP1
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Products associated with anti-ACAP1 antibody
Pathways associated with anti-ACAP1 antibody
Diseases associated with anti-ACAP1 antibody
Organs/Tissues associated with anti-ACAP1 antibody
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