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anti-CISD2 antibody :: Rabbit anti-Human CISD2 Polyclonal Antibody

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Catalog # MBS7003489
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

CISD2, Polyclonal Antibody

Popular Item
Full Product Name

CISD2 Antibody

Product Synonym Names
CDGSH iron-sulfur domain-containing protein 2; Endoplasmic reticulum intermembrane small protein; MitoNEET-related 1 protein; Miner1; Nutrient-deprivation autophagy factor-1; NAF-1; CISD2; CDGSH2; ERIS; ZCD2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
604928
3D Structure
ModBase 3D Structure for Q8N5K1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%,Protein G purified
Form/Format
Liquid
Immunogen
Recombinant human CDGSH iron-sulfur domain-containing protein 2 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CISD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CISD2 antibody
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
Applications Tested/Suitable for anti-CISD2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunohistochemistry (IHC) of anti-CISD2 antibody
Immunohistochemistry of paraffin-embedded human pancreatic tissue using MBS7003489 at dilution of 1:100
anti-CISD2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CISD2 antibody
Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7003489 at dilution of 1:100
anti-CISD2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CISD2 antibody
Immunofluorescent analysis of Hela cells using MBS7003489 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-CISD2 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-CISD2 antibody
Western Blot
Positive WB detected in:Hela whole cell lysate,HepG2 whole cell lysate,Mouse spleen tissue,Mouse lung tissue,Mouse kidney tissue,Mouse brain tissue
All lanes: CISD2 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 16 kDa
Observed band size: 16 kDa

anti-CISD2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for CISD2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,278 Da
NCBI Official Full Name
CDGSH iron-sulfur domain-containing protein 2
NCBI Official Synonym Full Names
CDGSH iron sulfur domain 2
NCBI Official Symbol
CISD2  [Similar Products]
NCBI Official Synonym Symbols
ERIS; WFS2; ZCD2; NAF-1; Miner1
  [Similar Products]
NCBI Protein Information
CDGSH iron-sulfur domain-containing protein 2
UniProt Protein Name
CDGSH iron-sulfur domain-containing protein 2
UniProt Synonym Protein Names
Endoplasmic reticulum intermembrane small protein; MitoNEET-related 1 protein; Miner1; Nutrient-deprivation autophagy factor-1; NAF-1
UniProt Gene Name
CISD2  [Similar Products]
UniProt Synonym Gene Names
CDGSH2; ERIS; ZCD2; Miner1; NAF-1  [Similar Products]
UniProt Entry Name
CISD2_HUMAN
NCBI Summary for CISD2
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
UniProt Comments for CISD2
CISD2: a single-pass membrane protein of the endoplasmic reticulum that regulates autophagy. Has also been reported to localize to the mitochondrion outer membrane. Antagonizes ATG6-mediated cellular autophagy. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. Directly interacts with BCL2; the interaction is disrupted by BIK interaction with BCL2. It has been reported to mainly localizes to the mitochondrion outer membrane. Defects in CISD2 are the cause of Wolfram syndrome 2 (WFS2), is a rare autosomal recessive disorder characterized by optic atrophy and diabetes mellitus. Other symptoms include the presence of profound upper gastrointestinal ulceration, significant bleeding tendency, defective platelet aggregation with collagen and various neurological symptoms. Initially thought to be a zinc-finger protein, it was later shown to bind 1 2Fe-2S cluster instead.

Protein type: Endoplasmic reticulum; Autophagy; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane; mitochondrial outer membrane; protein complex

Molecular Function: 2 iron, 2 sulfur cluster binding; metal ion binding; protein binding; protein homodimerization activity

Biological Process: mitochondrion degradation; multicellular organismal aging; regulation of autophagy

Disease: Wolfram Syndrome 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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