NP_597724
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
18,569 Da
NCBI Official Full Name
cbp/p300-interacting transactivator 4
NCBI Official Synonym Full Names
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
NCBI Protein Information
cbp/p300-interacting transactivator 4
UniProt Protein Name
Cbp/p300-interacting transactivator 4
UniProt Synonym Protein Names
MSG1-related protein 2; MRG-2
UniProt Synonym Gene Names
NCBI Summary for CITED4
The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]
UniProt Comments for CITED4
Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.
Research Articles on CITED4
Precautions
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Products associated with anti-CITED4 antibody
Pathways associated with anti-CITED4 antibody
Diseases associated with anti-CITED4 antibody
Organs/Tissues associated with anti-CITED4 antibody
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