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anti-CLASP2 antibody :: Rabbit anti-Human CLASP2 Polyclonal Antibody

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Catalog # MBS7002720
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

CLASP2, Polyclonal Antibody

Popular Item
Also Known As

CLASP2 Antibody

Product Synonym Names
CLIP-associating protein 2; CLASP2; KIAA0627; Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1294
OMIM
605853
3D Structure
ModBase 3D Structure for O75122
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity Purified
Form/Format
Liquid
Immunogen
Recombinant human CLIP-associating protein 2 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-102447 / sc-102445 / sc-98440
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CLASP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CLASP2 antibody
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Applications Tested/Suitable for anti-CLASP2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-CLASP2 antibody
Recommended dilution: IHC: 1:20-1:200

Immunohistochemistry (IHC) of anti-CLASP2 antibody
Immunohistochemistry of paraffin-embedded human liver cancer tissue using MBS7002720 at dilution 1:100
anti-CLASP2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CLASP2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
165,924 Da
NCBI Official Full Name
CLIP-associating protein 2 isoform 2
NCBI Official Synonym Full Names
cytoplasmic linker associated protein 2
NCBI Official Symbol
CLASP2  [Similar Products]
NCBI Protein Information
CLIP-associating protein 2
UniProt Protein Name
CLIP-associating protein 2
UniProt Synonym Protein Names
Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2
Protein Family
UniProt Gene Name
CLASP2  [Similar Products]
UniProt Synonym Gene Names
KIAA0627; hOrbit2  [Similar Products]
UniProt Entry Name
CLAP2_HUMAN
UniProt Comments for CLASP2
CLASP2: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Belongs to the CLASP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: basal cortex; cell cortex; cytoplasm; cytoplasmic microtubule; cytosol; focal adhesion; Golgi apparatus; kinetochore; kinetochore microtubule; leading edge; membrane; microtubule; microtubule organizing center; plasma membrane; trans-Golgi network

Molecular Function: actin filament binding; microtubule binding; microtubule plus-end binding; protein binding

Biological Process: axon guidance; cell division; establishment and/or maintenance of cell polarity; exit from mitosis; Golgi organization and biogenesis; microtubule cytoskeleton organization and biogenesis; microtubule nucleation; microtubule organizing center organization and biogenesis; mitotic cell cycle; mitotic spindle organization and biogenesis; negative regulation of focal adhesion formation; negative regulation of microtubule depolymerization; negative regulation of stress fiber formation; positive regulation of exocytosis; regulation of actin cytoskeleton organization and biogenesis; regulation of axon extension; regulation of gastrulation; regulation of microtubule polymerization; regulation of microtubule polymerization or depolymerization; regulation of microtubule-based process; small GTPase mediated signal transduction; vesicle targeting
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-CLASP2 antibody
 Reference Product  PubMed Publications
 MAPRE1 antibody  >1 publications with CLASP2 and MAPRE1
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