NP_066924.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
22,744 Da
NCBI Official Full Name
claudin-1
NCBI Official Synonym Full Names
claudin 1
NCBI Protein Information
claudin-1
UniProt Protein Name
Claudin-1
UniProt Synonym Protein Names
Senescence-associated epithelial membrane protein
UniProt Synonym Gene Names
UniProt Entry Name
CLD1_HUMAN
NCBI Summary for CLDN1
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for CLDN1
Claudin-1: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Acts as a co- receptor for HCV entry into hepatic cells. Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL. May interact with HCV E1 and E2 proteins. Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. Belongs to the claudin family.
Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3q28-q29
Cellular Component: integral to membrane; integral to plasma membrane; tight junction
Molecular Function: identical protein binding; protein binding
Biological Process: calcium-independent cell-cell adhesion; intercellular junction assembly and maintenance; protein heterooligomerization; protein homooligomerization
Disease: Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis
Research Articles on CLDN1
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Products associated with anti-CLDN1 antibody
Pathways associated with anti-CLDN1 antibody
Diseases associated with anti-CLDN1 antibody
Organs/Tissues associated with anti-CLDN1 antibody
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