NP_001032406.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
47,743 Da
NCBI Official Full Name
cyclic nucleotide-gated cation channel alpha-4
NCBI Official Synonym Full Names
cyclic nucleotide gated channel alpha 4
NCBI Official Synonym Symbols
CNG4; CNG5; CNCA2; CNG-4; CNGB2; OCNC2; OCNCb; OCNCBETA [Similar Products]
NCBI Protein Information
cyclic nucleotide-gated cation channel alpha-4
UniProt Protein Name
Cyclic nucleotide-gated cation channel alpha-4
UniProt Synonym Protein Names
Cyclic nucleotide-gated channel alpha-4; CNG channel alpha-4; CNG-4; CNG4
UniProt Synonym Gene Names
UniProt Entry Name
CNGA4_HUMAN
NCBI Summary for CNGA4
CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]
UniProt Comments for CNGA4
CNGA4: Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: Golgi membrane; intracellular cyclic nucleotide activated cation channel complex; perikaryon
Molecular Function: cAMP binding; cGMP binding; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; voltage-gated potassium channel activity
Biological Process: organelle organization and biogenesis; protein heterotetramerization; regulation of membrane potential; response to stimulus; sensory perception of smell
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Pathways associated with anti-CNGA4 antibody
Organs/Tissues associated with anti-CNGA4 antibody
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