NP_061971.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 92 kDa Predicted: 93 kDa
NCBI Official Full Name
cyclic nucleotide-gated cation channel beta-3
NCBI Official Synonym Full Names
cyclic nucleotide gated channel beta 3
NCBI Official Synonym Symbols
NCBI Protein Information
cyclic nucleotide-gated cation channel beta-3
UniProt Protein Name
Cyclic nucleotide-gated cation channel beta-3
UniProt Synonym Protein Names
Cone photoreceptor cGMP-gated channel subunit beta; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-3; CNG channel beta-3
UniProt Synonym Gene Names
NCBI Summary for CNGB3
This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010]
UniProt Comments for CNGB3
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
Research Articles on CNGB3
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Products associated with anti-CNGB3 antibody
Pathways associated with anti-CNGB3 antibody
Diseases associated with anti-CNGB3 antibody
Organs/Tissues associated with anti-CNGB3 antibody
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