NP_001193940.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,633 Da
NCBI Official Full Name
ciliary neurotrophic factor receptor subunit alpha preproprotein
NCBI Official Synonym Full Names
ciliary neurotrophic factor receptor
NCBI Protein Information
ciliary neurotrophic factor receptor subunit alpha
UniProt Protein Name
Ciliary neurotrophic factor receptor subunit alpha
UniProt Synonym Gene Names
NCBI Summary for CNTFR
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]
UniProt Comments for CNTFR
Binds to CNTF. The alpha subunit provides the receptor specificity.
Product References and Citations for anti-CNTFR antibody
(1) Rousseau, F., Gauchat, J.F., McLeod, J.G, et, al Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient. PNAS.2008; 105 (35):10068-10073.
Research Articles on CNTFR
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-CNTFR antibody
Diseases associated with anti-CNTFR antibody
Organs/Tissues associated with anti-CNTFR antibody
|