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anti-COTL1 antibody :: Rabbit anti-Human Coactosin Like Protein 1 Polyclonal Antibody

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Catalog # MBS2026807 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $110 +1 FREE 8GB USB
  0.02 mg  /  $130 +1 FREE 8GB USB
  0.05 mg  /  $175 +1 FREE 8GB USB
  0.1 mg  /  $225 +1 FREE 8GB USB
  0.2 mg  /  $340 +1 FREE 8GB USB
  1 mg  /  $800 +1 FREE 8GB USB
Product Name

Coactosin Like Protein 1 (COTL1), Polyclonal Antibody

Popular Item
Full Product Name

Polyclonal Antibody to Coactosin Like Protein 1 (COTL1)

Matching Pairs
Matching Pairs
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
L54057 mRNA
3D Structure
ModBase 3D Structure for Q14019
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody is a rabbit polyclonal antibody raised against COTL1. It has beenselected for its ability to recognize COTL1 in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Liquid
Concentration
200ug/ml (lot specific)
Fragment
COTL1 (Met1~Glu142)
Organism Species
Homo sapiens (Human)
Conjugate
No Conjugate
Immunogen
Recombinant COTL1 (Met1~Glu142) expressed in E Coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2081254
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-COTL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-COTL1 antibody
Applications Tested/Suitable for anti-COTL1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-COTL1 antibody
Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-COTL1 antibody
Western Blot: Sample: Lane1: Human Lung Tissue; Lane2: Human Hela Cells; Lane3: Mouse Placenta Tissue; Lane4: Mouse Kidney Tissue.
anti-COTL1 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-COTL1 antibody
Western Blot: Sample: Recombinant COTL1, Human.
anti-COTL1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-COTL1 antibody
DAB staining on IHC-P; Samples: Human Glioma Tissue.
anti-COTL1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-COTL1 antibody
DAB staining on IHC-P; Samples: Human Kidney Tissue
anti-COTL1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-COTL1 antibody
DAB staining on IHC-P; Samples: Human Prostate Gland Tissue
anti-COTL1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-COTL1 antibody
FITC staining on IHC-P Simple: Hela cells)
anti-COTL1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-COTL1 antibody
DAB staining on IHC-P; Samples: Human Breast Cancer Tissue
anti-COTL1 antibody Immunohistochemistry (IHC) (IHC) image
Knockout Validation of anti-COTL1 antibody
Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: COTL1 knockout Hela cell lysate; Predicted MW: 16kd Observed MW: 16kd Primary Ab: 1ug/ml Rabbit Anti-Human COTL1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047)
anti-COTL1 antibody Knockout Validation image
NCBI/Uniprot data below describe general gene information for COTL1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,945 Da
NCBI Official Full Name
coactosin-like protein
NCBI Official Synonym Full Names
coactosin like F-actin binding protein 1
NCBI Official Symbol
COTL1  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
coactosin-like protein
UniProt Protein Name
Coactosin-like protein
Protein Family
UniProt Gene Name
COTL1  [Similar Products]
UniProt Synonym Gene Names
NCBI Summary for COTL1
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]
UniProt Comments for COTL1
COTL1: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Belongs to the actin-binding proteins ADF family. Coactosin subfamily.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: cytoskeleton; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; nucleus; secretory granule lumen

Molecular Function: actin binding; enzyme binding; protein binding

Biological Process: defense response to fungus; neutrophil degranulation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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