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anti-COL4A6 antibody :: Goat COL4A6 Polyclonal Antibody

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Catalog # MBS421733
Unit / Price
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  0.1 mg  /  $225 +1 FREE 8GB USB
anti-COL4A6 antibody
Product Name

COL4A6, Polyclonal Antibody

Popular Item
Full Product Name

Goat anti-COL4A6 Antibody

Product Synonym Names
COL4A6; collagen, type IV, alpha 6; MGC88184; OTTHUMP00000023834; OTTHUMP00000023835; collagen IV, alpha-6 polypeptide; collagen alpha 6 type IV; collagen of basement membrane, alpha-6; dJ889N15.4 (Collagen Alpha 6(IV)); type IV alpha 6 collagen; COL4A6 antibody; collagen; type IV; alpha 6 antibody; MGC88184 antibody; OTTHUMP00000023834 antibody; OTTHUMP00000023835 antibody; collagen IV; alpha-6 polypeptide antibody; collagen alpha 6 type IV antibody; collagen of basement membrane; alpha-6 antibody; dJ889N15.4 (Collagen Alpha 6(IV)) antibody; type IV alpha 6 collagen antibody
Antibody/Peptide Pairs
COL4A6 peptide (MBS425045) is used for blocking the activity of COL4A6 antibody (MBS421733)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
PSPEFETETL HNKES
OMIM
300914
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-PSPEFETETLHNKES, from the internal region of the protein sequence according to NP_001838.2; NP_378667.1.
Epitope
Internal region
Note
This antibody is expected to recognize both reported isoforms (NP_001838.2; NP_378667.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-COL4A6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-COL4A6 antibody
Peptide ELISA (EIA)
Application Notes for anti-COL4A6 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave an approx 20kDa band in Human Heart, Kidney and Skeletal Muscle lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 164kDa according to NP_001838.2 and NP_378667.1. The 20kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for COL4A6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_378667.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
163,629 Da
NCBI Official Full Name
collagen alpha-6(IV) chain isoform A
NCBI Official Synonym Full Names
collagen type IV alpha 6
NCBI Official Symbol
COL4A6  [Similar Products]
NCBI Official Synonym Symbols
DFNX6; DELXq22.3; CXDELq22.3
  [Similar Products]
NCBI Protein Information
collagen alpha-6(IV) chain
UniProt Protein Name
Collagen alpha-6(IV) chain
Protein Family
UniProt Gene Name
COL4A6  [Similar Products]
UniProt Entry Name
CO4A6_HUMAN
NCBI Summary for COL4A6
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
UniProt Comments for COL4A6
COL4A6: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Deletions covering the N-terminal regions of COL4A5 and COL4A6, which are localized in a head-to-head manner, are found in the chromosome Xq22.3 centromeric deletion syndrome. This results in a phenotype with features of diffuse leiomyomatosis and Alport syndrome (DL-ATS). Belongs to the type IV collagen family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: collagen type IV; endoplasmic reticulum lumen; extracellular region

Molecular Function: extracellular matrix structural constituent

Biological Process: cell adhesion; collagen catabolic process; extracellular matrix organization and biogenesis

Disease: Deafness, X-linked 6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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